4-Aminoethylamino-emodin – a novel potent inhibitor of GSK-3β– acts as an insulin-sensitizer avoiding downstream effects of activated β-catenin

Glycogen synthase kinase-3β (GSK-3β) is a key target and effector of downstream insulin signalling. Using comparative protein kinase assays and molecular docking studies we characterize the emodin-derivative 4-[N-2-(aminoethyl)-amino]-emodin (L4) as a sensitive and potent inhibitor of GSK-3β with pe...

Descripción completa

Detalles Bibliográficos
Autores principales: Gebhardt, Rolf, Lerche, Katja S, Götschel, Frank, Günther, Robert, Kolander, Jens, Teich, Lars, Zellmer, Sebastian, Hofmann, Hans-Jörg, Eger, Kurt, Hecht, Andreas, Gaunitz, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828845/
https://www.ncbi.nlm.nih.gov/pubmed/19228266
http://dx.doi.org/10.1111/j.1582-4934.2009.00701.x

Ejemplares similares

Ejemplares similares