Hepatoprotective Activity of the Ethanolic Extract of Ficus caricaLinn. LeavesinCarbon Tetrachloride-Induced Hepatotoxicityin Rats

The ethanolic extract of Ficus carica leaves was screened for hepatoprotective and antioxidant activity in hepatotoxic Albino rats induced via carbon tetrachloride. The degree of protection was measured by estimating biochemical parameters such as serum glutamate Oxaloacetate transaminase (SGOT), se...

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Detalles Bibliográficos
Autores principales: Mujeeb, Mohd, Alam Khan, Shah, Aeri, Vidhu, Ali, Babar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828912/
https://www.ncbi.nlm.nih.gov/pubmed/24250358
Descripción
Sumario:The ethanolic extract of Ficus carica leaves was screened for hepatoprotective and antioxidant activity in hepatotoxic Albino rats induced via carbon tetrachloride. The degree of protection was measured by estimating biochemical parameters such as serum glutamate Oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase ( SGPT),totalprotein (TP), totalalbumin (TA), alkaline phosphatase (ALKP) and the level of total serum bilirubin. The extract in addition reduced CCl(4) induced lipid peroxidation in-vivo and in-vitro. The ethanolic extract (50 mg/kg, 100mg/kg,200mg/kg)exhibited significant hepatoprotection incarbontetra chloride in toxicated rats in a dose dependant manner. The hepatoprotective effects of the extract were comparable with the standard drug silymarin 10)mg/kg body weight, IP).

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