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Synthesis and In-vitro Antibacterial Activities of Acetylanthracene and Acetylphenanthrene Derivatives of Some Fluoroquinolones
Novel analogues of N-piperazinyl fluoroquinolones were prepared and evaluated against a panel of Gram-positive and Gram-negative bacteria, to study the effect of introducing bulky anthracene and phenanthrene moieties on the antibacterial effects of norfloxacin, ciprofloxacin and gatifloxacin. Althou...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828925/ https://www.ncbi.nlm.nih.gov/pubmed/24250347 |
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author | Shamsa, Fazel Foroumadi, Alireza Shamsa, Hashim Samadi, Nasrin Faramarzi, Mohammad Ali Shafiee, Abbas |
author_facet | Shamsa, Fazel Foroumadi, Alireza Shamsa, Hashim Samadi, Nasrin Faramarzi, Mohammad Ali Shafiee, Abbas |
author_sort | Shamsa, Fazel |
collection | PubMed |
description | Novel analogues of N-piperazinyl fluoroquinolones were prepared and evaluated against a panel of Gram-positive and Gram-negative bacteria, to study the effect of introducing bulky anthracene and phenanthrene moieties on the antibacterial effects of norfloxacin, ciprofloxacin and gatifloxacin. Although most of the novel synthesized compounds had lower antibacterial effects, some derivatives showed better activity in comparison with mother drugs based on molar concentration; for example, the 3-acetyl phenanthrene analogue of norfloxacin was more effective than E. coli and K. pneumonia. |
format | Online Article Text |
id | pubmed-3828925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-38289252013-11-18 Synthesis and In-vitro Antibacterial Activities of Acetylanthracene and Acetylphenanthrene Derivatives of Some Fluoroquinolones Shamsa, Fazel Foroumadi, Alireza Shamsa, Hashim Samadi, Nasrin Faramarzi, Mohammad Ali Shafiee, Abbas Iran J Pharm Res Original Article Novel analogues of N-piperazinyl fluoroquinolones were prepared and evaluated against a panel of Gram-positive and Gram-negative bacteria, to study the effect of introducing bulky anthracene and phenanthrene moieties on the antibacterial effects of norfloxacin, ciprofloxacin and gatifloxacin. Although most of the novel synthesized compounds had lower antibacterial effects, some derivatives showed better activity in comparison with mother drugs based on molar concentration; for example, the 3-acetyl phenanthrene analogue of norfloxacin was more effective than E. coli and K. pneumonia. Shaheed Beheshti University of Medical Sciences 2011 /pmc/articles/PMC3828925/ /pubmed/24250347 Text en © 2011 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Shamsa, Fazel Foroumadi, Alireza Shamsa, Hashim Samadi, Nasrin Faramarzi, Mohammad Ali Shafiee, Abbas Synthesis and In-vitro Antibacterial Activities of Acetylanthracene and Acetylphenanthrene Derivatives of Some Fluoroquinolones |
title | Synthesis and In-vitro Antibacterial Activities of Acetylanthracene and Acetylphenanthrene Derivatives of Some Fluoroquinolones |
title_full | Synthesis and In-vitro Antibacterial Activities of Acetylanthracene and Acetylphenanthrene Derivatives of Some Fluoroquinolones |
title_fullStr | Synthesis and In-vitro Antibacterial Activities of Acetylanthracene and Acetylphenanthrene Derivatives of Some Fluoroquinolones |
title_full_unstemmed | Synthesis and In-vitro Antibacterial Activities of Acetylanthracene and Acetylphenanthrene Derivatives of Some Fluoroquinolones |
title_short | Synthesis and In-vitro Antibacterial Activities of Acetylanthracene and Acetylphenanthrene Derivatives of Some Fluoroquinolones |
title_sort | synthesis and in-vitro antibacterial activities of acetylanthracene and acetylphenanthrene derivatives of some fluoroquinolones |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828925/ https://www.ncbi.nlm.nih.gov/pubmed/24250347 |
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