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Directed Evolution of an Angiopoietin-2 Ligand Trap by Somatic Hypermutation and Cell Surface Display

Tie2 is a receptor tyrosine kinase that is essential for the development and maintenance of blood vessels through binding the soluble ligands angiopoietin 1 (Ang1) and 2 (Ang2). Ang1 is constitutively produced by perivascular cells and is protective of the adult vasculature. Ang2 plays an important...

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Detalles Bibliográficos
Autores principales:	Brindle, Nicholas P. J., Sale, Julian E., Arakawa, Hiroshi, Buerstedde, Jean-Marie, Nuamchit, Teonchit, Sharma, Shikha, Steele, Kathryn H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829167/ https://www.ncbi.nlm.nih.gov/pubmed/24106271 http://dx.doi.org/10.1074/jbc.M113.510578

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