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Animal models of ulcerative colitis and their application in drug research

The specific pathogenesis underlying inflammatory bowel disease is complex, and it is even more difficult to decipher the pathophysiology to explain for the similarities and differences between two of its major subtypes, Crohn’s disease and ulcerative colitis (UC). Animal models are indispensable to...

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Detalles Bibliográficos
Autores principales: Low, Daren, Nguyen, Deanna D, Mizoguchi, Emiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829622/
https://www.ncbi.nlm.nih.gov/pubmed/24250223
http://dx.doi.org/10.2147/DDDT.S40107
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author Low, Daren
Nguyen, Deanna D
Mizoguchi, Emiko
author_facet Low, Daren
Nguyen, Deanna D
Mizoguchi, Emiko
author_sort Low, Daren
collection PubMed
description The specific pathogenesis underlying inflammatory bowel disease is complex, and it is even more difficult to decipher the pathophysiology to explain for the similarities and differences between two of its major subtypes, Crohn’s disease and ulcerative colitis (UC). Animal models are indispensable to pry into mechanistic details that will facilitate better preclinical drug/therapy design to target specific components involved in the disease pathogenesis. This review focuses on common animal models that are particularly useful for the study of UC and its therapeutic strategy. Recent reports of the latest compounds, therapeutic strategies, and approaches tested on UC animal models are also discussed.
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spelling pubmed-38296222013-11-18 Animal models of ulcerative colitis and their application in drug research Low, Daren Nguyen, Deanna D Mizoguchi, Emiko Drug Des Devel Ther Review The specific pathogenesis underlying inflammatory bowel disease is complex, and it is even more difficult to decipher the pathophysiology to explain for the similarities and differences between two of its major subtypes, Crohn’s disease and ulcerative colitis (UC). Animal models are indispensable to pry into mechanistic details that will facilitate better preclinical drug/therapy design to target specific components involved in the disease pathogenesis. This review focuses on common animal models that are particularly useful for the study of UC and its therapeutic strategy. Recent reports of the latest compounds, therapeutic strategies, and approaches tested on UC animal models are also discussed. Dove Medical Press 2013-11-12 /pmc/articles/PMC3829622/ /pubmed/24250223 http://dx.doi.org/10.2147/DDDT.S40107 Text en © 2013 Low et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Low, Daren
Nguyen, Deanna D
Mizoguchi, Emiko
Animal models of ulcerative colitis and their application in drug research
title Animal models of ulcerative colitis and their application in drug research
title_full Animal models of ulcerative colitis and their application in drug research
title_fullStr Animal models of ulcerative colitis and their application in drug research
title_full_unstemmed Animal models of ulcerative colitis and their application in drug research
title_short Animal models of ulcerative colitis and their application in drug research
title_sort animal models of ulcerative colitis and their application in drug research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829622/
https://www.ncbi.nlm.nih.gov/pubmed/24250223
http://dx.doi.org/10.2147/DDDT.S40107
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