The Hedgehog inhibitor cyclopamine antagonizes chemoresistance of breast cancer cells

Chemoresistance of cancer cells has been a severe problem in multiple types of cancers. One possibility is to combine different drugs with chemotherapy for improved efficacy. Cyclopamine blocks Hedgehog signaling by antagonizing Smo function, which induces tumor apoptosis. Here, we show that the com...

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Autores principales: Chai, Feng, Zhou, Jiangang, Chen, Cheng, Xie, Song, Chen, Xiao, Su, Ping, Shi, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829677/
https://www.ncbi.nlm.nih.gov/pubmed/24250231
http://dx.doi.org/10.2147/OTT.S51914
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author Chai, Feng
Zhou, Jiangang
Chen, Cheng
Xie, Song
Chen, Xiao
Su, Ping
Shi, Jun
author_facet Chai, Feng
Zhou, Jiangang
Chen, Cheng
Xie, Song
Chen, Xiao
Su, Ping
Shi, Jun
author_sort Chai, Feng
collection PubMed
description Chemoresistance of cancer cells has been a severe problem in multiple types of cancers. One possibility is to combine different drugs with chemotherapy for improved efficacy. Cyclopamine blocks Hedgehog signaling by antagonizing Smo function, which induces tumor apoptosis. Here, we show that the combined use of cyclopamine and paclitaxel (chemotherapy drugs) was able to induce breast cancer cell apoptosis both in vivo and in vitro. The results suggest that Hedgehog signaling is a prospective drug target for chemoresistant cancer cells.
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spelling pubmed-38296772013-11-18 The Hedgehog inhibitor cyclopamine antagonizes chemoresistance of breast cancer cells Chai, Feng Zhou, Jiangang Chen, Cheng Xie, Song Chen, Xiao Su, Ping Shi, Jun Onco Targets Ther Original Research Chemoresistance of cancer cells has been a severe problem in multiple types of cancers. One possibility is to combine different drugs with chemotherapy for improved efficacy. Cyclopamine blocks Hedgehog signaling by antagonizing Smo function, which induces tumor apoptosis. Here, we show that the combined use of cyclopamine and paclitaxel (chemotherapy drugs) was able to induce breast cancer cell apoptosis both in vivo and in vitro. The results suggest that Hedgehog signaling is a prospective drug target for chemoresistant cancer cells. Dove Medical Press 2013-11-12 /pmc/articles/PMC3829677/ /pubmed/24250231 http://dx.doi.org/10.2147/OTT.S51914 Text en © 2013 Chai et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Chai, Feng
Zhou, Jiangang
Chen, Cheng
Xie, Song
Chen, Xiao
Su, Ping
Shi, Jun
The Hedgehog inhibitor cyclopamine antagonizes chemoresistance of breast cancer cells
title The Hedgehog inhibitor cyclopamine antagonizes chemoresistance of breast cancer cells
title_full The Hedgehog inhibitor cyclopamine antagonizes chemoresistance of breast cancer cells
title_fullStr The Hedgehog inhibitor cyclopamine antagonizes chemoresistance of breast cancer cells
title_full_unstemmed The Hedgehog inhibitor cyclopamine antagonizes chemoresistance of breast cancer cells
title_short The Hedgehog inhibitor cyclopamine antagonizes chemoresistance of breast cancer cells
title_sort hedgehog inhibitor cyclopamine antagonizes chemoresistance of breast cancer cells
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829677/
https://www.ncbi.nlm.nih.gov/pubmed/24250231
http://dx.doi.org/10.2147/OTT.S51914
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