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Parasite co-infections show synergistic and antagonistic interactions on growth performance of East African zebu cattle under one year
The co-occurrence of different pathogen species and their simultaneous infection of hosts are common, and may affect host health outcomes. Co-infecting pathogens may interact synergistically (harming the host more) or antagonistically (harming the host less) compared with single infections. Here we...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829697/ https://www.ncbi.nlm.nih.gov/pubmed/24001119 http://dx.doi.org/10.1017/S0031182013001261 |
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author | THUMBI, S. M. de. C. BRONSVOORT, B. M. POOLE, E. J. KIARA, H. TOYE, P. NDILA, M. CONRADIE, I. JENNINGS, A. HANDEL, I. G. COETZER, J. A. W. HANOTTE, O. WOOLHOUSE, M. E. J. |
author_facet | THUMBI, S. M. de. C. BRONSVOORT, B. M. POOLE, E. J. KIARA, H. TOYE, P. NDILA, M. CONRADIE, I. JENNINGS, A. HANDEL, I. G. COETZER, J. A. W. HANOTTE, O. WOOLHOUSE, M. E. J. |
author_sort | THUMBI, S. M. |
collection | PubMed |
description | The co-occurrence of different pathogen species and their simultaneous infection of hosts are common, and may affect host health outcomes. Co-infecting pathogens may interact synergistically (harming the host more) or antagonistically (harming the host less) compared with single infections. Here we have tested associations of infections and their co-infections with variation in growth rate using a subset of 455 animals of the Infectious Diseases of East Africa Livestock (IDEAL) cohort study surviving to one year. Data on live body weight, infections with helminth parasites and haemoparasites were collected every 5 weeks during the first year of life. Growth of zebu cattle during the first year of life was best described by a linear growth function. A large variation in daily weight gain with a range of 0·03–0·34 kg, and a mean of 0·135 kg (0·124, 0·146; 95% CI) was observed. After controlling for other significant covariates in mixed effects statistical models, the results revealed synergistic interactions (lower growth rates) with Theileria parva and Anaplasma marginale co-infections, and antagonistic interactions (relatively higher growth rates) with T. parva and Theileria mutans co-infections, compared with infections with T. parva only. Additionally, helminth infections can have a strong negative effect on the growth rates but this is burden-dependent, accounting for up to 30% decrease in growth rate in heavily infected animals. These findings present evidence of pathogen–pathogen interactions affecting host growth, and we discuss possible mechanisms that may explain observed directions of interactions as well as possible modifications to disease control strategies when co-infections are present. |
format | Online Article Text |
id | pubmed-3829697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-38296972013-11-18 Parasite co-infections show synergistic and antagonistic interactions on growth performance of East African zebu cattle under one year THUMBI, S. M. de. C. BRONSVOORT, B. M. POOLE, E. J. KIARA, H. TOYE, P. NDILA, M. CONRADIE, I. JENNINGS, A. HANDEL, I. G. COETZER, J. A. W. HANOTTE, O. WOOLHOUSE, M. E. J. Parasitology Research Article The co-occurrence of different pathogen species and their simultaneous infection of hosts are common, and may affect host health outcomes. Co-infecting pathogens may interact synergistically (harming the host more) or antagonistically (harming the host less) compared with single infections. Here we have tested associations of infections and their co-infections with variation in growth rate using a subset of 455 animals of the Infectious Diseases of East Africa Livestock (IDEAL) cohort study surviving to one year. Data on live body weight, infections with helminth parasites and haemoparasites were collected every 5 weeks during the first year of life. Growth of zebu cattle during the first year of life was best described by a linear growth function. A large variation in daily weight gain with a range of 0·03–0·34 kg, and a mean of 0·135 kg (0·124, 0·146; 95% CI) was observed. After controlling for other significant covariates in mixed effects statistical models, the results revealed synergistic interactions (lower growth rates) with Theileria parva and Anaplasma marginale co-infections, and antagonistic interactions (relatively higher growth rates) with T. parva and Theileria mutans co-infections, compared with infections with T. parva only. Additionally, helminth infections can have a strong negative effect on the growth rates but this is burden-dependent, accounting for up to 30% decrease in growth rate in heavily infected animals. These findings present evidence of pathogen–pathogen interactions affecting host growth, and we discuss possible mechanisms that may explain observed directions of interactions as well as possible modifications to disease control strategies when co-infections are present. Cambridge University Press 2013-12 2013-09-04 /pmc/articles/PMC3829697/ /pubmed/24001119 http://dx.doi.org/10.1017/S0031182013001261 Text en © Cambridge University Press 2013 The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution licence <http://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Research Article THUMBI, S. M. de. C. BRONSVOORT, B. M. POOLE, E. J. KIARA, H. TOYE, P. NDILA, M. CONRADIE, I. JENNINGS, A. HANDEL, I. G. COETZER, J. A. W. HANOTTE, O. WOOLHOUSE, M. E. J. Parasite co-infections show synergistic and antagonistic interactions on growth performance of East African zebu cattle under one year |
title | Parasite co-infections show synergistic and antagonistic interactions on growth performance of East African zebu cattle under one year |
title_full | Parasite co-infections show synergistic and antagonistic interactions on growth performance of East African zebu cattle under one year |
title_fullStr | Parasite co-infections show synergistic and antagonistic interactions on growth performance of East African zebu cattle under one year |
title_full_unstemmed | Parasite co-infections show synergistic and antagonistic interactions on growth performance of East African zebu cattle under one year |
title_short | Parasite co-infections show synergistic and antagonistic interactions on growth performance of East African zebu cattle under one year |
title_sort | parasite co-infections show synergistic and antagonistic interactions on growth performance of east african zebu cattle under one year |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829697/ https://www.ncbi.nlm.nih.gov/pubmed/24001119 http://dx.doi.org/10.1017/S0031182013001261 |
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