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Left and right ventricular structure and function in subclinical hypothyroidism: The effects of one-year levothyroxine treatment
BACKGROUND: The aim of this study was to investigate left ventricular (LV) and right ventricular (RV) structure, function, and mechanics in patients with subclinical hypothyroidism (SHT), and to evaluate the effect of a 1-year levothyroxine treatment. MATERIAL/METHODS: We compared 45 untreated women...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829699/ https://www.ncbi.nlm.nih.gov/pubmed/24217559 http://dx.doi.org/10.12659/MSM.889621 |
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author | Ilic, Sanja Tadic, Marijana Ivanovic, Branislava Caparevic, Zorica Trbojevic, Boza Celic, Vera |
author_facet | Ilic, Sanja Tadic, Marijana Ivanovic, Branislava Caparevic, Zorica Trbojevic, Boza Celic, Vera |
author_sort | Ilic, Sanja |
collection | PubMed |
description | BACKGROUND: The aim of this study was to investigate left ventricular (LV) and right ventricular (RV) structure, function, and mechanics in patients with subclinical hypothyroidism (SHT), and to evaluate the effect of a 1-year levothyroxine treatment. MATERIAL/METHODS: We compared 45 untreated women with subclinical hypothyroidism and 35 healthy control women matched by age. All the subjects underwent laboratory analyses, which included a thyroid hormone levels (free T3, free T4, and TSH) test, and a complete 2-dimensional echocardiographic study. All the SHT patients received levothyroxine therapy and were followed for a year after euthyroid state was achieved. RESULTS: The LV mass index in the SHT participants before and after replacement therapy was significantly higher than in controls. In the SHT patients before the treatment, LV diastolic function and global function estimated by the Tei index were significantly impaired, whereas the LV systolic function was decreased. The results show that LV mechanics was significantly impaired in the SHT patients at baseline. Additionally, the SHT participants before levothyroxine substitution had increased RV wall thickness and significantly impaired RV diastolic and global function in comparison with the controls or the SHT subjects after the treatment. Furthermore, RV mechanics was also significantly deteriorated in the SHT patients before the treatment. CONCLUSIONS: Subclinical hypothyroidism significantly affected LV and RV structure, systolic, diastolic and global function, and LV and RV mechanics. Levothyroxine replacement therapy significantly improved cardiac structure, function, and mechanics in the SHT patients. |
format | Online Article Text |
id | pubmed-3829699 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-38296992013-11-18 Left and right ventricular structure and function in subclinical hypothyroidism: The effects of one-year levothyroxine treatment Ilic, Sanja Tadic, Marijana Ivanovic, Branislava Caparevic, Zorica Trbojevic, Boza Celic, Vera Med Sci Monit Clinical Research BACKGROUND: The aim of this study was to investigate left ventricular (LV) and right ventricular (RV) structure, function, and mechanics in patients with subclinical hypothyroidism (SHT), and to evaluate the effect of a 1-year levothyroxine treatment. MATERIAL/METHODS: We compared 45 untreated women with subclinical hypothyroidism and 35 healthy control women matched by age. All the subjects underwent laboratory analyses, which included a thyroid hormone levels (free T3, free T4, and TSH) test, and a complete 2-dimensional echocardiographic study. All the SHT patients received levothyroxine therapy and were followed for a year after euthyroid state was achieved. RESULTS: The LV mass index in the SHT participants before and after replacement therapy was significantly higher than in controls. In the SHT patients before the treatment, LV diastolic function and global function estimated by the Tei index were significantly impaired, whereas the LV systolic function was decreased. The results show that LV mechanics was significantly impaired in the SHT patients at baseline. Additionally, the SHT participants before levothyroxine substitution had increased RV wall thickness and significantly impaired RV diastolic and global function in comparison with the controls or the SHT subjects after the treatment. Furthermore, RV mechanics was also significantly deteriorated in the SHT patients before the treatment. CONCLUSIONS: Subclinical hypothyroidism significantly affected LV and RV structure, systolic, diastolic and global function, and LV and RV mechanics. Levothyroxine replacement therapy significantly improved cardiac structure, function, and mechanics in the SHT patients. International Scientific Literature, Inc. 2013-11-10 /pmc/articles/PMC3829699/ /pubmed/24217559 http://dx.doi.org/10.12659/MSM.889621 Text en © Med Sci Monit, 2013 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License |
spellingShingle | Clinical Research Ilic, Sanja Tadic, Marijana Ivanovic, Branislava Caparevic, Zorica Trbojevic, Boza Celic, Vera Left and right ventricular structure and function in subclinical hypothyroidism: The effects of one-year levothyroxine treatment |
title | Left and right ventricular structure and function in subclinical hypothyroidism: The effects of one-year levothyroxine treatment |
title_full | Left and right ventricular structure and function in subclinical hypothyroidism: The effects of one-year levothyroxine treatment |
title_fullStr | Left and right ventricular structure and function in subclinical hypothyroidism: The effects of one-year levothyroxine treatment |
title_full_unstemmed | Left and right ventricular structure and function in subclinical hypothyroidism: The effects of one-year levothyroxine treatment |
title_short | Left and right ventricular structure and function in subclinical hypothyroidism: The effects of one-year levothyroxine treatment |
title_sort | left and right ventricular structure and function in subclinical hypothyroidism: the effects of one-year levothyroxine treatment |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829699/ https://www.ncbi.nlm.nih.gov/pubmed/24217559 http://dx.doi.org/10.12659/MSM.889621 |
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