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Urinary TNF-α and NGAL are correlated with the progression of nephropathy in patients with type 2 diabetes
The aim of this study was to investigate the correlation of the proinflammatory marker tumor necrosis factor-α (TNF-α) and the tubular marker neutrophil gelatinase-associated lipocalin (NGAL) with the progression of the early stage of type 2 diabetic nephropathy (DN). Baseline levels of urinary TNF-...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829713/ https://www.ncbi.nlm.nih.gov/pubmed/24250725 http://dx.doi.org/10.3892/etm.2013.1315 |
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author | WU, JIAN DING, YAQING ZHU, CHUNLING SHAO, XIAOHONG XIE, XIN LU, KAN WANG, RUI |
author_facet | WU, JIAN DING, YAQING ZHU, CHUNLING SHAO, XIAOHONG XIE, XIN LU, KAN WANG, RUI |
author_sort | WU, JIAN |
collection | PubMed |
description | The aim of this study was to investigate the correlation of the proinflammatory marker tumor necrosis factor-α (TNF-α) and the tubular marker neutrophil gelatinase-associated lipocalin (NGAL) with the progression of the early stage of type 2 diabetic nephropathy (DN). Baseline levels of urinary TNF-α and NGAL were measured in 63 non-diabetic controls and 201 patients with type 2 diabetes and different albuminuria statuses. The patients with diabetes (n=125) with normo- or microalbuminuria were subsequently followed-up for 28 (25–32) months, with routine measurements of creatinine and urinary albumin excretion (UAE). It was observed that baseline levels of urinary TNF-α and NGAL were significantly elevated and correlated with the severity of albuminuria in patients with diabetes. During the follow-up, the urinary levels of TNF-α and NGAL were observed to be significantly correlated with a rapid decline in the estimated glomerular filtration rate (eGFR). Following adjustment for other progression promoters, including albuminuria, TNF-α remained a significant predictor of eGFR decline. These results suggest that inflammation is important in the pathogenesis of DN and indicate that TNF-α may be used as an independent predictor for the progression of DN at the early stage. |
format | Online Article Text |
id | pubmed-3829713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-38297132013-11-18 Urinary TNF-α and NGAL are correlated with the progression of nephropathy in patients with type 2 diabetes WU, JIAN DING, YAQING ZHU, CHUNLING SHAO, XIAOHONG XIE, XIN LU, KAN WANG, RUI Exp Ther Med Articles The aim of this study was to investigate the correlation of the proinflammatory marker tumor necrosis factor-α (TNF-α) and the tubular marker neutrophil gelatinase-associated lipocalin (NGAL) with the progression of the early stage of type 2 diabetic nephropathy (DN). Baseline levels of urinary TNF-α and NGAL were measured in 63 non-diabetic controls and 201 patients with type 2 diabetes and different albuminuria statuses. The patients with diabetes (n=125) with normo- or microalbuminuria were subsequently followed-up for 28 (25–32) months, with routine measurements of creatinine and urinary albumin excretion (UAE). It was observed that baseline levels of urinary TNF-α and NGAL were significantly elevated and correlated with the severity of albuminuria in patients with diabetes. During the follow-up, the urinary levels of TNF-α and NGAL were observed to be significantly correlated with a rapid decline in the estimated glomerular filtration rate (eGFR). Following adjustment for other progression promoters, including albuminuria, TNF-α remained a significant predictor of eGFR decline. These results suggest that inflammation is important in the pathogenesis of DN and indicate that TNF-α may be used as an independent predictor for the progression of DN at the early stage. D.A. Spandidos 2013-12 2013-09-26 /pmc/articles/PMC3829713/ /pubmed/24250725 http://dx.doi.org/10.3892/etm.2013.1315 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles WU, JIAN DING, YAQING ZHU, CHUNLING SHAO, XIAOHONG XIE, XIN LU, KAN WANG, RUI Urinary TNF-α and NGAL are correlated with the progression of nephropathy in patients with type 2 diabetes |
title | Urinary TNF-α and NGAL are correlated with the progression of nephropathy in patients with type 2 diabetes |
title_full | Urinary TNF-α and NGAL are correlated with the progression of nephropathy in patients with type 2 diabetes |
title_fullStr | Urinary TNF-α and NGAL are correlated with the progression of nephropathy in patients with type 2 diabetes |
title_full_unstemmed | Urinary TNF-α and NGAL are correlated with the progression of nephropathy in patients with type 2 diabetes |
title_short | Urinary TNF-α and NGAL are correlated with the progression of nephropathy in patients with type 2 diabetes |
title_sort | urinary tnf-α and ngal are correlated with the progression of nephropathy in patients with type 2 diabetes |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829713/ https://www.ncbi.nlm.nih.gov/pubmed/24250725 http://dx.doi.org/10.3892/etm.2013.1315 |
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