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Urinary TNF-α and NGAL are correlated with the progression of nephropathy in patients with type 2 diabetes

The aim of this study was to investigate the correlation of the proinflammatory marker tumor necrosis factor-α (TNF-α) and the tubular marker neutrophil gelatinase-associated lipocalin (NGAL) with the progression of the early stage of type 2 diabetic nephropathy (DN). Baseline levels of urinary TNF-...

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Autores principales: WU, JIAN, DING, YAQING, ZHU, CHUNLING, SHAO, XIAOHONG, XIE, XIN, LU, KAN, WANG, RUI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829713/
https://www.ncbi.nlm.nih.gov/pubmed/24250725
http://dx.doi.org/10.3892/etm.2013.1315
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author WU, JIAN
DING, YAQING
ZHU, CHUNLING
SHAO, XIAOHONG
XIE, XIN
LU, KAN
WANG, RUI
author_facet WU, JIAN
DING, YAQING
ZHU, CHUNLING
SHAO, XIAOHONG
XIE, XIN
LU, KAN
WANG, RUI
author_sort WU, JIAN
collection PubMed
description The aim of this study was to investigate the correlation of the proinflammatory marker tumor necrosis factor-α (TNF-α) and the tubular marker neutrophil gelatinase-associated lipocalin (NGAL) with the progression of the early stage of type 2 diabetic nephropathy (DN). Baseline levels of urinary TNF-α and NGAL were measured in 63 non-diabetic controls and 201 patients with type 2 diabetes and different albuminuria statuses. The patients with diabetes (n=125) with normo- or microalbuminuria were subsequently followed-up for 28 (25–32) months, with routine measurements of creatinine and urinary albumin excretion (UAE). It was observed that baseline levels of urinary TNF-α and NGAL were significantly elevated and correlated with the severity of albuminuria in patients with diabetes. During the follow-up, the urinary levels of TNF-α and NGAL were observed to be significantly correlated with a rapid decline in the estimated glomerular filtration rate (eGFR). Following adjustment for other progression promoters, including albuminuria, TNF-α remained a significant predictor of eGFR decline. These results suggest that inflammation is important in the pathogenesis of DN and indicate that TNF-α may be used as an independent predictor for the progression of DN at the early stage.
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spelling pubmed-38297132013-11-18 Urinary TNF-α and NGAL are correlated with the progression of nephropathy in patients with type 2 diabetes WU, JIAN DING, YAQING ZHU, CHUNLING SHAO, XIAOHONG XIE, XIN LU, KAN WANG, RUI Exp Ther Med Articles The aim of this study was to investigate the correlation of the proinflammatory marker tumor necrosis factor-α (TNF-α) and the tubular marker neutrophil gelatinase-associated lipocalin (NGAL) with the progression of the early stage of type 2 diabetic nephropathy (DN). Baseline levels of urinary TNF-α and NGAL were measured in 63 non-diabetic controls and 201 patients with type 2 diabetes and different albuminuria statuses. The patients with diabetes (n=125) with normo- or microalbuminuria were subsequently followed-up for 28 (25–32) months, with routine measurements of creatinine and urinary albumin excretion (UAE). It was observed that baseline levels of urinary TNF-α and NGAL were significantly elevated and correlated with the severity of albuminuria in patients with diabetes. During the follow-up, the urinary levels of TNF-α and NGAL were observed to be significantly correlated with a rapid decline in the estimated glomerular filtration rate (eGFR). Following adjustment for other progression promoters, including albuminuria, TNF-α remained a significant predictor of eGFR decline. These results suggest that inflammation is important in the pathogenesis of DN and indicate that TNF-α may be used as an independent predictor for the progression of DN at the early stage. D.A. Spandidos 2013-12 2013-09-26 /pmc/articles/PMC3829713/ /pubmed/24250725 http://dx.doi.org/10.3892/etm.2013.1315 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
WU, JIAN
DING, YAQING
ZHU, CHUNLING
SHAO, XIAOHONG
XIE, XIN
LU, KAN
WANG, RUI
Urinary TNF-α and NGAL are correlated with the progression of nephropathy in patients with type 2 diabetes
title Urinary TNF-α and NGAL are correlated with the progression of nephropathy in patients with type 2 diabetes
title_full Urinary TNF-α and NGAL are correlated with the progression of nephropathy in patients with type 2 diabetes
title_fullStr Urinary TNF-α and NGAL are correlated with the progression of nephropathy in patients with type 2 diabetes
title_full_unstemmed Urinary TNF-α and NGAL are correlated with the progression of nephropathy in patients with type 2 diabetes
title_short Urinary TNF-α and NGAL are correlated with the progression of nephropathy in patients with type 2 diabetes
title_sort urinary tnf-α and ngal are correlated with the progression of nephropathy in patients with type 2 diabetes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829713/
https://www.ncbi.nlm.nih.gov/pubmed/24250725
http://dx.doi.org/10.3892/etm.2013.1315
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