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Lentinus edodes promotes fat removal in hypercholesterolemic mice

Lentinus (L.) edodes (shiitake mushroom) is used as a traditional medicine in Asia. One of the components of L. edodes, eritadenine (an adenosine analog alkaloid), has been shown to reduce cholesterol levels. The hypocholesterolemic action of eritadenine appears to be achieved through the modificati...

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Autores principales: YANG, HYUN, HWANG, INHO, KIM, SUN, HONG, EUI-JU, JEUNG, EUI-BAE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829752/
https://www.ncbi.nlm.nih.gov/pubmed/24255670
http://dx.doi.org/10.3892/etm.2013.1333
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author YANG, HYUN
HWANG, INHO
KIM, SUN
HONG, EUI-JU
JEUNG, EUI-BAE
author_facet YANG, HYUN
HWANG, INHO
KIM, SUN
HONG, EUI-JU
JEUNG, EUI-BAE
author_sort YANG, HYUN
collection PubMed
description Lentinus (L.) edodes (shiitake mushroom) is used as a traditional medicine in Asia. One of the components of L. edodes, eritadenine (an adenosine analog alkaloid), has been shown to reduce cholesterol levels. The hypocholesterolemic action of eritadenine appears to be achieved through the modification of hepatic phospholipid metabolism. In the present study, the effects of L. edodes in a mouse model of hypercholesterolemia were investigated. Hypercholesterolemia was induced by the consumption of a high-fat diet (HFD). The animals were divided into six groups, which were fed a normal diet, HFD alone, HFD containing eritadenine [10 mg/kg of body weight (BW)] or HFD with 5, 10 or 20% L. edodes, respectively, for 4 weeks (from 5 to 9 weeks of age). The mice in the six groups had similar BW gains. Total serum cholesterol (T-CHO), low-density lipoprotein (LDL) and triglyceride (TG) levels were increased in the HFD-fed group compared with those in the normal diet group. However, the levels of high-density lipoprotein (HDL) were not significantly altered. In mice treated with L. edodes (5, 10 or 20%), the T-CHO, LDL and TG serum levels were reduced in a dose-dependent manner. The mRNA expression of cholesterol 7-α-hydroxylase 1 (CYP7A1) was decreased in hypercholesterolemic mice and increased by eritadenine and L. edodes (5, 10 and 20%) supplementation. In liver tissues, it was observed that lipid accumulation was reduced by treatment with eritadenine and L. edodes. In addition, it was revealed that the formation of atherosclerotic plaques due to the HFD was also suppressed by eritadenine and L. edodes. The results of the study indicated that the consumption of an HFD may inhibit CYP7A1 expression in the liver by increasing serum T-CHO, LDL and TG levels. L. edodes may help regulate lipid metabolism, suggesting that this fungus ameliorates hypercholesterolemia in mice by regulating CYP7A1 expression in the liver.
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spelling pubmed-38297522013-11-19 Lentinus edodes promotes fat removal in hypercholesterolemic mice YANG, HYUN HWANG, INHO KIM, SUN HONG, EUI-JU JEUNG, EUI-BAE Exp Ther Med Articles Lentinus (L.) edodes (shiitake mushroom) is used as a traditional medicine in Asia. One of the components of L. edodes, eritadenine (an adenosine analog alkaloid), has been shown to reduce cholesterol levels. The hypocholesterolemic action of eritadenine appears to be achieved through the modification of hepatic phospholipid metabolism. In the present study, the effects of L. edodes in a mouse model of hypercholesterolemia were investigated. Hypercholesterolemia was induced by the consumption of a high-fat diet (HFD). The animals were divided into six groups, which were fed a normal diet, HFD alone, HFD containing eritadenine [10 mg/kg of body weight (BW)] or HFD with 5, 10 or 20% L. edodes, respectively, for 4 weeks (from 5 to 9 weeks of age). The mice in the six groups had similar BW gains. Total serum cholesterol (T-CHO), low-density lipoprotein (LDL) and triglyceride (TG) levels were increased in the HFD-fed group compared with those in the normal diet group. However, the levels of high-density lipoprotein (HDL) were not significantly altered. In mice treated with L. edodes (5, 10 or 20%), the T-CHO, LDL and TG serum levels were reduced in a dose-dependent manner. The mRNA expression of cholesterol 7-α-hydroxylase 1 (CYP7A1) was decreased in hypercholesterolemic mice and increased by eritadenine and L. edodes (5, 10 and 20%) supplementation. In liver tissues, it was observed that lipid accumulation was reduced by treatment with eritadenine and L. edodes. In addition, it was revealed that the formation of atherosclerotic plaques due to the HFD was also suppressed by eritadenine and L. edodes. The results of the study indicated that the consumption of an HFD may inhibit CYP7A1 expression in the liver by increasing serum T-CHO, LDL and TG levels. L. edodes may help regulate lipid metabolism, suggesting that this fungus ameliorates hypercholesterolemia in mice by regulating CYP7A1 expression in the liver. D.A. Spandidos 2013-12 2013-10-08 /pmc/articles/PMC3829752/ /pubmed/24255670 http://dx.doi.org/10.3892/etm.2013.1333 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
YANG, HYUN
HWANG, INHO
KIM, SUN
HONG, EUI-JU
JEUNG, EUI-BAE
Lentinus edodes promotes fat removal in hypercholesterolemic mice
title Lentinus edodes promotes fat removal in hypercholesterolemic mice
title_full Lentinus edodes promotes fat removal in hypercholesterolemic mice
title_fullStr Lentinus edodes promotes fat removal in hypercholesterolemic mice
title_full_unstemmed Lentinus edodes promotes fat removal in hypercholesterolemic mice
title_short Lentinus edodes promotes fat removal in hypercholesterolemic mice
title_sort lentinus edodes promotes fat removal in hypercholesterolemic mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829752/
https://www.ncbi.nlm.nih.gov/pubmed/24255670
http://dx.doi.org/10.3892/etm.2013.1333
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