CYP2B6 Non-Coding Variation Associated with Smoking Cessation Is Also Associated with Differences in Allelic Expression, Splicing, and Nicotine Metabolism Independent of Common Amino-Acid Changes

The Cytochrome P450 2B6 (CYP2B6) enzyme makes a small contribution to hepatic nicotine metabolism relative to CYP2A6, but CYP2B6 is the primary enzyme responsible for metabolism of the smoking cessation drug bupropion. Using CYP2A6 genotype as a covariate, we find that a non-coding polymorphism in C...

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Detalles Bibliográficos
Autores principales: Bloom, A. Joseph, Martinez, Maribel, Chen, Li-Shiun, Bierut, Laura J., Murphy, Sharon E., Goate, Alison
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829832/
https://www.ncbi.nlm.nih.gov/pubmed/24260284
http://dx.doi.org/10.1371/journal.pone.0079700

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