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Development and Implementation of a High-Throughput Compound Screening Assay for Targeting Disrupted ER Calcium Homeostasis in Alzheimer's Disease

Disrupted intracellular calcium homeostasis is believed to occur early in the cascade of events leading to Alzheimer's disease (AD) pathology. Particularly familial AD mutations linked to Presenilins result in exaggerated agonist-evoked calcium release from endoplasmic reticulum (ER). Here we r...

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Detalles Bibliográficos
Autores principales:	Honarnejad, Kamran, Daschner, Alexander, Giese, Armin, Zall, Andrea, Schmidt, Boris, Szybinska, Aleksandra, Kuznicki, Jacek, Herms, Jochen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829862/ https://www.ncbi.nlm.nih.gov/pubmed/24260442 http://dx.doi.org/10.1371/journal.pone.0080645

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