Conjugation of Benzylvanillin and Benzimidazole Structure Improves DNA Binding with Enhanced Antileukemic Properties

Benzyl-o-vanillin and benzimidazole nucleus serve as important pharmacophore in drug discovery. The benzyl vanillin (2-(benzyloxy)-3-methoxybenzaldehyde) compound shows anti-proliferative activity in HL60 leukemia cancer cells and can effect cell cycle progression at G2/M phase. Its apoptosis activi...

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Detalles Bibliográficos
Autores principales: Al-Mudaris, Zena A., Majid, Aman S. A., Ji, Dan, Al-Mudarris, Ban A., Chen, Shih-Hsun, Liang, Po-Huang, Osman, Hasnah, Jamal Din, Shah Kamal Khan, Abdul Majid, Amin M. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829952/
https://www.ncbi.nlm.nih.gov/pubmed/24260527
http://dx.doi.org/10.1371/journal.pone.0080983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829952/
https://www.ncbi.nlm.nih.gov/pubmed/24260527
http://dx.doi.org/10.1371/journal.pone.0080983

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