Cargando…

Valproic Acid Regulates α-Synuclein Expression through JNK Pathway in Rat Primary Astrocytes

Although the role of α-synuclein aggregation on Parkinson’s disease is relatively well known, the physiological role and the regulatory mechanism governing the expression of α-synuclein are unclear yet. We recently reported that α-synuclein is expressed and secreted from cultured astrocytes. In this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Jung Nam, Kim, Min Kyeong, Cho, Kyu Suk, Choi, Chang Soon, Park, Seung Hwa, Yang, Sung-Il, Joo, So Hyun, Park, Jin Hee, Bahn, Geonho, Shin, Chan Young, Lee, He-Jin, Han, Seol-Heui, Kwon, Kyoung Ja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society of Applied Pharmacology 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830121/ https://www.ncbi.nlm.nih.gov/pubmed/24265868 http://dx.doi.org/10.4062/biomolther.2013.006

Ejemplares similares

Transcriptional Upregulation of Plasminogen Activator Inhibitor-1 in Rat Primary Astrocytes by a Proteasomal Inhibitor MG132
por: Cho, Kyu Suk, et al.
Publicado: (2013)

Effects of Korean Red Ginseng extract on tissue plasminogen activator and plasminogen activator inhibitor-1 expression in cultured rat primary astrocytes
por: Ko, Hyun Myung, et al.
Publicado: (2013)

Valproic Acid Induces Telomerase Reverse Transcriptase Expression during Cortical Development
por: Kim, Ki Chan, et al.
Publicado: (2017)

The transgenerational inheritance of autism-like phenotypes in mice exposed to valproic acid during pregnancy
por: Choi, Chang Soon, et al.
Publicado: (2016)

Erratum: Valproic Acid Induces Telomerase Reverse Transcriptase Expression during Cortical Development
por: Kim, Ki Chan, et al.
Publicado: (2017)

Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes
por: Bang, Minji, et al.
Publicado: (2019)

Minoxidil Regulates Aging-Like Phenotypes in Rat Cortical Astrocytes (In Vitro)
por: Bang, Minji, et al.
Publicado: (2023)

Gastrointestinal Tract Abnormalities Induced by Prenatal Valproic Acid Exposure in Rat Offspring
por: Kim, Ji-Woon, et al.
Publicado: (2013)

The Synucleins and the Astrocyte
por: Myers, Abigail J., et al.
Publicado: (2023)

In Vitro and In Vivo Radiosensitizing Effect of Valproic Acid on Fractionated Irradiation
por: Chie, Eui Kyu, et al.
Publicado: (2015)

Subchronic Treatment of Donepezil Rescues Impaired Social, Hyperactive, and Stereotypic Behavior in Valproic Acid-Induced Animal Model of Autism
por: Kim, Ji-Woon, et al.
Publicado: (2014)

Alpha-synuclein stimulation of astrocytes: Potential role for neuroinflammation and neuroprotection
por: Lee, He-Jin, et al.
Publicado: (2010)

Therapeutic functions of astrocytes to treat α-synuclein pathology in Parkinson’s disease
por: Yang, Yunseon, et al.
Publicado: (2022)

p21-activated kinase 4 controls the aggregation of α-synuclein by reducing the monomeric and aggregated forms of α-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1
por: Won, So-Yoon, et al.
Publicado: (2022)

Valproic acid inhibits neural progenitor cell death by activation of NF-κB signaling pathway and up-regulation of Bcl-XL
por: Go, Hyo Sang, et al.
Publicado: (2011)

Assessment of C-phycocyanin effect on astrocytes-mediated neuroprotection against oxidative brain injury using 2D and 3D astrocyte tissue model
por: Min, Seul Ki, et al.
Publicado: (2015)

Melatonin Potentiates the Neuroprotective Properties of Resveratrol Against Beta-Amyloid-Induced Neurodegeneration by Modulating AMP-Activated Protein Kinase Pathways
por: Kwon, Kyoung Ja, et al.
Publicado: (2010)

PT580. Alteration of neuronal nitric oxide synthase dimerization contributes to the development of Alzheimer’s disease
por: Kyoung, Ja Kwon, et al.
Publicado: (2016)

Valproic acid-exposed astrocytes impair inhibitory synapse formation and function
por: Takeda, Kotomi, et al.
Publicado: (2021)

Valproic acid-induced changes of 4D nuclear morphology in astrocyte cells
por: Kalinin, Alexandr A., et al.
Publicado: (2021)

Dasatinib Accelerates Valproic Acid-Induced Acute Myeloid Leukemia Cell Death by Regulation of Differentiation Capacity
por: Heo, Sook-Kyoung, et al.
Publicado: (2014)

Early Postnatal Valproic Acid Exposure Increase the Protein Level of Astrocyte Markers in Frontal Cortex of Rat
por: Mony, Tamanna Jahan, et al.
Publicado: (2018)

Alternations of Septal-hippocampal System in the Adult Wistar Rat with Spatial Memory Impairments Induced by Chronic Cerebral Hypoperfusion
por: Choi, Bo-Ryoung, et al.
Publicado: (2011)

HMGB1 induces hepcidin upregulation in astrocytes and causes an acute iron surge and subsequent ferroptosis in the postischemic brain
por: Davaanyam, Dashdulam, et al.
Publicado: (2023)

Sex Differences in Autism-Like Behavioral Phenotypes and Postsynaptic Receptors Expression in the Prefrontal Cortex of TERT Transgenic Mice
por: Kim, Ki Chan, et al.
Publicado: (2017)

Astrocytes Reduce Store-Operated Ca(2+) Entry in Microglia under the Conditions of an Inflammatory Stimulus and Muscarinic Receptor Blockade
por: Kim, Yoo Jin, et al.
Publicado: (2022)

HSP70-mediated neuroprotection by combined treatment of valproic acid with hypothermia in a rat asphyxial cardiac arrest model
por: Oh, Joo Suk, et al.
Publicado: (2021)

The Neuroprotective Effect of Treatment of Valproic Acid in Acute Spinal Cord Injury
por: Yu, Song-Hee, et al.
Publicado: (2012)

Monitoring α-synuclein Aggregation Induced by Preformed α-synuclein Fibrils in an In Vitro Model System
por: Kim, Beom Jin, et al.
Publicado: (2023)

Association of Geriatric Syndromes with Urinary Incontinence according to Sex and Urinary-Incontinence–Related Quality of Life in Older Inpatients: A Cross-Sectional Study of an Acute Care Hospital
por: Kim, Kyoung Jin, et al.
Publicado: (2019)

Astaxanthin Suppresses PM2.5-Induced Neuroinflammation by Regulating Akt Phosphorylation in BV-2 Microglial Cells
por: Kim, Ryeong-Eun, et al.
Publicado: (2020)

Valproic Acid-induced Hyperammonemic Encephalopathy Promoted by Levetiracetam
por: Roh, Sook Young, et al.
Publicado: (2014)

Anti-oxidative effects of 4-hydroxybenzyl alcohol in astrocytes confer protective effects in autocrine and paracrine manners
por: Luo, Lidan, et al.
Publicado: (2017)

DJ-1 deficiency impairs glutamate uptake into astrocytes via the regulation of flotillin-1 and caveolin-1 expression
por: Kim, Jin-Mo, et al.
Publicado: (2016)

Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes
por: Gustafsson, Gabriel, et al.
Publicado: (2017)

Astrocytes, Microglia, and Parkinson's Disease
por: Joe, Eun-Hye, et al.
Publicado: (2018)

Novel Therapeutics for Treating Sleep Disorders: New Perspectives on Maydis stigma
por: Kim, Ryeong-Eun, et al.
Publicado: (2022)

Tetraspanin-2 promotes glucotoxic apoptosis by regulating the JNK/β-catenin signaling pathway in human pancreatic β cells
por: Hwang, In-Hu, et al.
Publicado: (2016)

Bacterial Lipoproteins Induce BAFF Production via TLR2/MyD88/JNK Signaling Pathways in Dendritic Cells
por: Im, Jintaek, et al.
Publicado: (2020)

Celastrol suppresses expression of adhesion molecules and chemokines by inhibiting JNK-STAT1/NF-κB activation in poly(I:C)-stimulated astrocytes
por: An, Soo Yeon, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_33tnqa0m92n06pkmm6huo8m1dc