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Cell cycle regulation by long non-coding RNAs
The mammalian cell cycle is precisely controlled by cyclin-dependent kinases (CDKs) and related pathways such as the RB and p53 pathways. Recent research on long non-coding RNAs (lncRNAs) indicates that many lncRNAs are involved in the regulation of critical cell cycle regulators such as the cyclins...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Basel
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830198/ https://www.ncbi.nlm.nih.gov/pubmed/23880895 http://dx.doi.org/10.1007/s00018-013-1423-0 |
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author | Kitagawa, Masatoshi Kitagawa, Kyoko Kotake, Yojiro Niida, Hiroyuki Ohhata, Tatsuya |
author_facet | Kitagawa, Masatoshi Kitagawa, Kyoko Kotake, Yojiro Niida, Hiroyuki Ohhata, Tatsuya |
author_sort | Kitagawa, Masatoshi |
collection | PubMed |
description | The mammalian cell cycle is precisely controlled by cyclin-dependent kinases (CDKs) and related pathways such as the RB and p53 pathways. Recent research on long non-coding RNAs (lncRNAs) indicates that many lncRNAs are involved in the regulation of critical cell cycle regulators such as the cyclins, CDKs, CDK inhibitors, pRB, and p53. These lncRNAs act as epigenetic regulators, transcription factor regulators, post-transcription regulators, and protein scaffolds. These cell cycle-regulated lncRNAs mainly control cellular levels of cell cycle regulators via various mechanisms, and may provide diversity and reliability to the general cell cycle. Interestingly, several lncRNAs are induced by DNA damage and participate in cell cycle arrest or induction of apoptosis as DNA damage responses. Therefore, deregulations of these cell cycle regulatory lncRNAs may be involved in tumorigenesis, and they are novel candidate molecular targets for cancer therapy and diagnosis. |
format | Online Article Text |
id | pubmed-3830198 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer Basel |
record_format | MEDLINE/PubMed |
spelling | pubmed-38301982013-11-26 Cell cycle regulation by long non-coding RNAs Kitagawa, Masatoshi Kitagawa, Kyoko Kotake, Yojiro Niida, Hiroyuki Ohhata, Tatsuya Cell Mol Life Sci Review The mammalian cell cycle is precisely controlled by cyclin-dependent kinases (CDKs) and related pathways such as the RB and p53 pathways. Recent research on long non-coding RNAs (lncRNAs) indicates that many lncRNAs are involved in the regulation of critical cell cycle regulators such as the cyclins, CDKs, CDK inhibitors, pRB, and p53. These lncRNAs act as epigenetic regulators, transcription factor regulators, post-transcription regulators, and protein scaffolds. These cell cycle-regulated lncRNAs mainly control cellular levels of cell cycle regulators via various mechanisms, and may provide diversity and reliability to the general cell cycle. Interestingly, several lncRNAs are induced by DNA damage and participate in cell cycle arrest or induction of apoptosis as DNA damage responses. Therefore, deregulations of these cell cycle regulatory lncRNAs may be involved in tumorigenesis, and they are novel candidate molecular targets for cancer therapy and diagnosis. Springer Basel 2013-07-24 2013 /pmc/articles/PMC3830198/ /pubmed/23880895 http://dx.doi.org/10.1007/s00018-013-1423-0 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Review Kitagawa, Masatoshi Kitagawa, Kyoko Kotake, Yojiro Niida, Hiroyuki Ohhata, Tatsuya Cell cycle regulation by long non-coding RNAs |
title | Cell cycle regulation by long non-coding RNAs |
title_full | Cell cycle regulation by long non-coding RNAs |
title_fullStr | Cell cycle regulation by long non-coding RNAs |
title_full_unstemmed | Cell cycle regulation by long non-coding RNAs |
title_short | Cell cycle regulation by long non-coding RNAs |
title_sort | cell cycle regulation by long non-coding rnas |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830198/ https://www.ncbi.nlm.nih.gov/pubmed/23880895 http://dx.doi.org/10.1007/s00018-013-1423-0 |
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