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Cell cycle regulation by long non-coding RNAs

The mammalian cell cycle is precisely controlled by cyclin-dependent kinases (CDKs) and related pathways such as the RB and p53 pathways. Recent research on long non-coding RNAs (lncRNAs) indicates that many lncRNAs are involved in the regulation of critical cell cycle regulators such as the cyclins...

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Autores principales: Kitagawa, Masatoshi, Kitagawa, Kyoko, Kotake, Yojiro, Niida, Hiroyuki, Ohhata, Tatsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Basel 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830198/
https://www.ncbi.nlm.nih.gov/pubmed/23880895
http://dx.doi.org/10.1007/s00018-013-1423-0
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author Kitagawa, Masatoshi
Kitagawa, Kyoko
Kotake, Yojiro
Niida, Hiroyuki
Ohhata, Tatsuya
author_facet Kitagawa, Masatoshi
Kitagawa, Kyoko
Kotake, Yojiro
Niida, Hiroyuki
Ohhata, Tatsuya
author_sort Kitagawa, Masatoshi
collection PubMed
description The mammalian cell cycle is precisely controlled by cyclin-dependent kinases (CDKs) and related pathways such as the RB and p53 pathways. Recent research on long non-coding RNAs (lncRNAs) indicates that many lncRNAs are involved in the regulation of critical cell cycle regulators such as the cyclins, CDKs, CDK inhibitors, pRB, and p53. These lncRNAs act as epigenetic regulators, transcription factor regulators, post-transcription regulators, and protein scaffolds. These cell cycle-regulated lncRNAs mainly control cellular levels of cell cycle regulators via various mechanisms, and may provide diversity and reliability to the general cell cycle. Interestingly, several lncRNAs are induced by DNA damage and participate in cell cycle arrest or induction of apoptosis as DNA damage responses. Therefore, deregulations of these cell cycle regulatory lncRNAs may be involved in tumorigenesis, and they are novel candidate molecular targets for cancer therapy and diagnosis.
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spelling pubmed-38301982013-11-26 Cell cycle regulation by long non-coding RNAs Kitagawa, Masatoshi Kitagawa, Kyoko Kotake, Yojiro Niida, Hiroyuki Ohhata, Tatsuya Cell Mol Life Sci Review The mammalian cell cycle is precisely controlled by cyclin-dependent kinases (CDKs) and related pathways such as the RB and p53 pathways. Recent research on long non-coding RNAs (lncRNAs) indicates that many lncRNAs are involved in the regulation of critical cell cycle regulators such as the cyclins, CDKs, CDK inhibitors, pRB, and p53. These lncRNAs act as epigenetic regulators, transcription factor regulators, post-transcription regulators, and protein scaffolds. These cell cycle-regulated lncRNAs mainly control cellular levels of cell cycle regulators via various mechanisms, and may provide diversity and reliability to the general cell cycle. Interestingly, several lncRNAs are induced by DNA damage and participate in cell cycle arrest or induction of apoptosis as DNA damage responses. Therefore, deregulations of these cell cycle regulatory lncRNAs may be involved in tumorigenesis, and they are novel candidate molecular targets for cancer therapy and diagnosis. Springer Basel 2013-07-24 2013 /pmc/articles/PMC3830198/ /pubmed/23880895 http://dx.doi.org/10.1007/s00018-013-1423-0 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review
Kitagawa, Masatoshi
Kitagawa, Kyoko
Kotake, Yojiro
Niida, Hiroyuki
Ohhata, Tatsuya
Cell cycle regulation by long non-coding RNAs
title Cell cycle regulation by long non-coding RNAs
title_full Cell cycle regulation by long non-coding RNAs
title_fullStr Cell cycle regulation by long non-coding RNAs
title_full_unstemmed Cell cycle regulation by long non-coding RNAs
title_short Cell cycle regulation by long non-coding RNAs
title_sort cell cycle regulation by long non-coding rnas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830198/
https://www.ncbi.nlm.nih.gov/pubmed/23880895
http://dx.doi.org/10.1007/s00018-013-1423-0
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