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Pigmentation in vitamin B12 deficiency masquerading Addison's pigmentation: A rare presentation
A 35-year-female presented with generalized weakness, weight loss, and progressive pigmentation was worked up for suspicion of Addisons disease. On examination hyper pigmentation was noted on both palmar and dorsal aspect of hands involving knuckles, creases, feet, tongue, oral mucosa and gluteal re...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830324/ https://www.ncbi.nlm.nih.gov/pubmed/24251178 http://dx.doi.org/10.4103/2230-8210.119591 |
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author | Agrawala, Ritesh Kumar Sahoo, Srikanta Kumar Choudhury, Arun Kumar Mohanty, Binoy Kumar Baliarsinha, Anoj Kumar |
author_facet | Agrawala, Ritesh Kumar Sahoo, Srikanta Kumar Choudhury, Arun Kumar Mohanty, Binoy Kumar Baliarsinha, Anoj Kumar |
author_sort | Agrawala, Ritesh Kumar |
collection | PubMed |
description | A 35-year-female presented with generalized weakness, weight loss, and progressive pigmentation was worked up for suspicion of Addisons disease. On examination hyper pigmentation was noted on both palmar and dorsal aspect of hands involving knuckles, creases, feet, tongue, oral mucosa and gluteal region. There was no evidence of hypocortisolemia as initially suspected, and literature search revealed a possibility of vitamin B12 deficiency. She had megaloblastic anemia with a low serum vitamin B12, mostly due to poor dietary intake. Her hyper pigmentation resolved with vitamin B12 supplementation. Skin biopsy showed increased pigmentation at stratum spinosum and basal-layer. The mechanism of hyper pigmentation in vitamin B12 deficiency was due to an increase in melanin synthesis. |
format | Online Article Text |
id | pubmed-3830324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38303242013-11-18 Pigmentation in vitamin B12 deficiency masquerading Addison's pigmentation: A rare presentation Agrawala, Ritesh Kumar Sahoo, Srikanta Kumar Choudhury, Arun Kumar Mohanty, Binoy Kumar Baliarsinha, Anoj Kumar Indian J Endocrinol Metab Brief Communication A 35-year-female presented with generalized weakness, weight loss, and progressive pigmentation was worked up for suspicion of Addisons disease. On examination hyper pigmentation was noted on both palmar and dorsal aspect of hands involving knuckles, creases, feet, tongue, oral mucosa and gluteal region. There was no evidence of hypocortisolemia as initially suspected, and literature search revealed a possibility of vitamin B12 deficiency. She had megaloblastic anemia with a low serum vitamin B12, mostly due to poor dietary intake. Her hyper pigmentation resolved with vitamin B12 supplementation. Skin biopsy showed increased pigmentation at stratum spinosum and basal-layer. The mechanism of hyper pigmentation in vitamin B12 deficiency was due to an increase in melanin synthesis. Medknow Publications & Media Pvt Ltd 2013-10 /pmc/articles/PMC3830324/ /pubmed/24251178 http://dx.doi.org/10.4103/2230-8210.119591 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Communication Agrawala, Ritesh Kumar Sahoo, Srikanta Kumar Choudhury, Arun Kumar Mohanty, Binoy Kumar Baliarsinha, Anoj Kumar Pigmentation in vitamin B12 deficiency masquerading Addison's pigmentation: A rare presentation |
title | Pigmentation in vitamin B12 deficiency masquerading Addison's pigmentation: A rare presentation |
title_full | Pigmentation in vitamin B12 deficiency masquerading Addison's pigmentation: A rare presentation |
title_fullStr | Pigmentation in vitamin B12 deficiency masquerading Addison's pigmentation: A rare presentation |
title_full_unstemmed | Pigmentation in vitamin B12 deficiency masquerading Addison's pigmentation: A rare presentation |
title_short | Pigmentation in vitamin B12 deficiency masquerading Addison's pigmentation: A rare presentation |
title_sort | pigmentation in vitamin b12 deficiency masquerading addison's pigmentation: a rare presentation |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830324/ https://www.ncbi.nlm.nih.gov/pubmed/24251178 http://dx.doi.org/10.4103/2230-8210.119591 |
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