Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood

Individuals carrying (GGGGCC) expanded repeats in the C9orf72 gene represent a significant portion of patients suffering from amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Elucidating how these expanded repeats cause “c9FTD/ALS” has since become an important goal of the fiel...

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Detalles Bibliográficos
Autores principales: Belzil, Veronique V., Bauer, Peter O., Prudencio, Mercedes, Gendron, Tania F., Stetler, Caroline T., Yan, Irene K., Pregent, Luc, Daughrity, Lillian, Baker, Matthew C., Rademakers, Rosa, Boylan, Kevin, Patel, Tushar C., Dickson, Dennis W., Petrucelli, Leonard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830740/
https://www.ncbi.nlm.nih.gov/pubmed/24166615
http://dx.doi.org/10.1007/s00401-013-1199-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830740/
https://www.ncbi.nlm.nih.gov/pubmed/24166615
http://dx.doi.org/10.1007/s00401-013-1199-1

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