Protection of Chinese painted quails (Coturnix chinensis) against a highly pathogenic H5N1 avian influenza virus strain after vaccination

Chinese painted quails immunized with a single dose (6 μg HA) of inactivated H5N1 (clade 1) influenza vaccine NIBRG-14 and challenged with 100 LD(50) of the heterologous A/Swan/Nagybaracska/01/06(H5N1) (clade 2.2) strain were protected, whereas unvaccinated quails died after challenge. No viral anti...

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Autores principales: Sarkadi, Julia, Jankovics, Mate, Kis, Zoltan, Skare, Jozsef, Fodor, Kinga, Gonczol, Eva, Visontai, Ildiko, Vajo, Zoltan, Jankovics, Istvan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2013
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830747/
https://www.ncbi.nlm.nih.gov/pubmed/23771736
http://dx.doi.org/10.1007/s00705-013-1754-z
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author Sarkadi, Julia
Jankovics, Mate
Kis, Zoltan
Skare, Jozsef
Fodor, Kinga
Gonczol, Eva
Visontai, Ildiko
Vajo, Zoltan
Jankovics, Istvan
author_facet Sarkadi, Julia
Jankovics, Mate
Kis, Zoltan
Skare, Jozsef
Fodor, Kinga
Gonczol, Eva
Visontai, Ildiko
Vajo, Zoltan
Jankovics, Istvan
author_sort Sarkadi, Julia
collection PubMed
description Chinese painted quails immunized with a single dose (6 μg HA) of inactivated H5N1 (clade 1) influenza vaccine NIBRG-14 and challenged with 100 LD(50) of the heterologous A/Swan/Nagybaracska/01/06(H5N1) (clade 2.2) strain were protected, whereas unvaccinated quails died after challenge. No viral antigens or RNA were detected in cloacal swabs from immunized animals. Sera obtained post-immunization gave low titres in serological assays against the vaccine and the challenge viruses. Our results demonstrate the protective efficacy of the NIBRG-14 strain against the challenge virus and the usefulness of these small birds in protection studies of influenza vaccines.
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spelling pubmed-38307472013-11-27 Protection of Chinese painted quails (Coturnix chinensis) against a highly pathogenic H5N1 avian influenza virus strain after vaccination Sarkadi, Julia Jankovics, Mate Kis, Zoltan Skare, Jozsef Fodor, Kinga Gonczol, Eva Visontai, Ildiko Vajo, Zoltan Jankovics, Istvan Arch Virol Brief Report Chinese painted quails immunized with a single dose (6 μg HA) of inactivated H5N1 (clade 1) influenza vaccine NIBRG-14 and challenged with 100 LD(50) of the heterologous A/Swan/Nagybaracska/01/06(H5N1) (clade 2.2) strain were protected, whereas unvaccinated quails died after challenge. No viral antigens or RNA were detected in cloacal swabs from immunized animals. Sera obtained post-immunization gave low titres in serological assays against the vaccine and the challenge viruses. Our results demonstrate the protective efficacy of the NIBRG-14 strain against the challenge virus and the usefulness of these small birds in protection studies of influenza vaccines. Springer Vienna 2013-06-15 2013 /pmc/articles/PMC3830747/ /pubmed/23771736 http://dx.doi.org/10.1007/s00705-013-1754-z Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Brief Report
Sarkadi, Julia
Jankovics, Mate
Kis, Zoltan
Skare, Jozsef
Fodor, Kinga
Gonczol, Eva
Visontai, Ildiko
Vajo, Zoltan
Jankovics, Istvan
Protection of Chinese painted quails (Coturnix chinensis) against a highly pathogenic H5N1 avian influenza virus strain after vaccination
title Protection of Chinese painted quails (Coturnix chinensis) against a highly pathogenic H5N1 avian influenza virus strain after vaccination
title_full Protection of Chinese painted quails (Coturnix chinensis) against a highly pathogenic H5N1 avian influenza virus strain after vaccination
title_fullStr Protection of Chinese painted quails (Coturnix chinensis) against a highly pathogenic H5N1 avian influenza virus strain after vaccination
title_full_unstemmed Protection of Chinese painted quails (Coturnix chinensis) against a highly pathogenic H5N1 avian influenza virus strain after vaccination
title_short Protection of Chinese painted quails (Coturnix chinensis) against a highly pathogenic H5N1 avian influenza virus strain after vaccination
title_sort protection of chinese painted quails (coturnix chinensis) against a highly pathogenic h5n1 avian influenza virus strain after vaccination
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830747/
https://www.ncbi.nlm.nih.gov/pubmed/23771736
http://dx.doi.org/10.1007/s00705-013-1754-z
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