LRRK2 phosphorylates novel tau epitopes and promotes tauopathy

Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of familial Parkinson’s disease (PD). The neuropathology of LRRK2-related PD is heterogeneous and can include aberrant tau phosphorylation or neurofibrillary tau pathology. Recently, LRRK2 has been shown...

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Detalles Bibliográficos
Autores principales: Bailey, Rachel M., Covy, Jason P., Melrose, Heather L., Rousseau, Linda, Watkinson, Ruth, Knight, Joshua, Miles, Sarah, Farrer, Matthew J., Dickson, Dennis W., Giasson, Benoit I., Lewis, Jada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830748/
https://www.ncbi.nlm.nih.gov/pubmed/24113872
http://dx.doi.org/10.1007/s00401-013-1188-4

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