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Rikkunshito, a Japanese Kampo Medicine, Ameliorates Decreased Feeding Behavior via Ghrelin and Serotonin 2B Receptor Signaling in a Novelty Stress Murine Model
We investigated the effects of rikkunshito (RKT), a ghrelin signal enhancer, on the decrease in food intake after exposure to novelty stress in mice. RKT administration (500 mg/kg, per os) improved the decrease in 6 h cumulative food intake. In control mice, the plasma acylated ghrelin levels signif...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830778/ https://www.ncbi.nlm.nih.gov/pubmed/24288687 http://dx.doi.org/10.1155/2013/792940 |
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author | Yamada, Chihiro Saegusa, Yayoi Nakagawa, Koji Ohnishi, Shunsuke Muto, Shuichi Nahata, Miwa Sadakane, Chiharu Hattori, Tomohisa Sakamoto, Naoya Takeda, Hiroshi |
author_facet | Yamada, Chihiro Saegusa, Yayoi Nakagawa, Koji Ohnishi, Shunsuke Muto, Shuichi Nahata, Miwa Sadakane, Chiharu Hattori, Tomohisa Sakamoto, Naoya Takeda, Hiroshi |
author_sort | Yamada, Chihiro |
collection | PubMed |
description | We investigated the effects of rikkunshito (RKT), a ghrelin signal enhancer, on the decrease in food intake after exposure to novelty stress in mice. RKT administration (500 mg/kg, per os) improved the decrease in 6 h cumulative food intake. In control mice, the plasma acylated ghrelin levels significantly increased by 24 h fasting. In contrast, the acylated ghrelin levels did not increase by fasting in mice exposed to the novelty stress. RKT administration to the novelty stress mice showed a significant increase in the acylated ghrelin levels compared with that in the distilled-water-treated control mice. Food intake after administering serotonin 2B (5-HT(2B)) receptor antagonists was evaluated to clarify the role of 5-HT(2B) receptor activation in the decrease in feeding behavior after novelty stress. SB215505 and SB204741, 5-HT(2B) receptor antagonists, significantly improved the decrease in food intake after exposure to novelty stress. A component of RKT, isoliquiritigenin, prevented the decrease in 6 h cumulative food intake. Isoliquiritigenin showed 5-HT(2B) receptor antagonistic activity in vitro. In conclusion, the results suggested that RKT improves the decrease in food intake after novelty stress probably via 5-HT(2B) receptor antagonism of isoliquiritigenin contained in RKT. |
format | Online Article Text |
id | pubmed-3830778 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38307782013-11-28 Rikkunshito, a Japanese Kampo Medicine, Ameliorates Decreased Feeding Behavior via Ghrelin and Serotonin 2B Receptor Signaling in a Novelty Stress Murine Model Yamada, Chihiro Saegusa, Yayoi Nakagawa, Koji Ohnishi, Shunsuke Muto, Shuichi Nahata, Miwa Sadakane, Chiharu Hattori, Tomohisa Sakamoto, Naoya Takeda, Hiroshi Biomed Res Int Research Article We investigated the effects of rikkunshito (RKT), a ghrelin signal enhancer, on the decrease in food intake after exposure to novelty stress in mice. RKT administration (500 mg/kg, per os) improved the decrease in 6 h cumulative food intake. In control mice, the plasma acylated ghrelin levels significantly increased by 24 h fasting. In contrast, the acylated ghrelin levels did not increase by fasting in mice exposed to the novelty stress. RKT administration to the novelty stress mice showed a significant increase in the acylated ghrelin levels compared with that in the distilled-water-treated control mice. Food intake after administering serotonin 2B (5-HT(2B)) receptor antagonists was evaluated to clarify the role of 5-HT(2B) receptor activation in the decrease in feeding behavior after novelty stress. SB215505 and SB204741, 5-HT(2B) receptor antagonists, significantly improved the decrease in food intake after exposure to novelty stress. A component of RKT, isoliquiritigenin, prevented the decrease in 6 h cumulative food intake. Isoliquiritigenin showed 5-HT(2B) receptor antagonistic activity in vitro. In conclusion, the results suggested that RKT improves the decrease in food intake after novelty stress probably via 5-HT(2B) receptor antagonism of isoliquiritigenin contained in RKT. Hindawi Publishing Corporation 2013 2013-10-29 /pmc/articles/PMC3830778/ /pubmed/24288687 http://dx.doi.org/10.1155/2013/792940 Text en Copyright © 2013 Chihiro Yamada et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yamada, Chihiro Saegusa, Yayoi Nakagawa, Koji Ohnishi, Shunsuke Muto, Shuichi Nahata, Miwa Sadakane, Chiharu Hattori, Tomohisa Sakamoto, Naoya Takeda, Hiroshi Rikkunshito, a Japanese Kampo Medicine, Ameliorates Decreased Feeding Behavior via Ghrelin and Serotonin 2B Receptor Signaling in a Novelty Stress Murine Model |
title | Rikkunshito, a Japanese Kampo Medicine, Ameliorates Decreased Feeding Behavior via Ghrelin and Serotonin 2B Receptor Signaling in a Novelty Stress Murine Model |
title_full | Rikkunshito, a Japanese Kampo Medicine, Ameliorates Decreased Feeding Behavior via Ghrelin and Serotonin 2B Receptor Signaling in a Novelty Stress Murine Model |
title_fullStr | Rikkunshito, a Japanese Kampo Medicine, Ameliorates Decreased Feeding Behavior via Ghrelin and Serotonin 2B Receptor Signaling in a Novelty Stress Murine Model |
title_full_unstemmed | Rikkunshito, a Japanese Kampo Medicine, Ameliorates Decreased Feeding Behavior via Ghrelin and Serotonin 2B Receptor Signaling in a Novelty Stress Murine Model |
title_short | Rikkunshito, a Japanese Kampo Medicine, Ameliorates Decreased Feeding Behavior via Ghrelin and Serotonin 2B Receptor Signaling in a Novelty Stress Murine Model |
title_sort | rikkunshito, a japanese kampo medicine, ameliorates decreased feeding behavior via ghrelin and serotonin 2b receptor signaling in a novelty stress murine model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830778/ https://www.ncbi.nlm.nih.gov/pubmed/24288687 http://dx.doi.org/10.1155/2013/792940 |
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