Total Chemical Synthesis of a Heterodimeric Interchain Bis-Lactam-Linked Peptide: Application to an Analogue of Human Insulin-Like Peptide 3

Nonreducible cystine isosteres represent important peptide design elements in that they can maintain a near-native tertiary conformation of the peptide while simultaneously extending the in vitro and in vivo half-life of the biomolecule. Examples of these cystine mimics include dicarba, diselenide,...

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Detalles Bibliográficos
Autores principales: Karas, John, Shabanpoor, Fazel, Hossain, Mohammed Akhter, Gardiner, James, Separovic, Frances, Wade, John D., Scanlon, Denis B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830869/
https://www.ncbi.nlm.nih.gov/pubmed/24288548
http://dx.doi.org/10.1155/2013/504260

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