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Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study

Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese...

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Autores principales: Hishida, Asahi, Wakai, Kenji, Naito, Mariko, Tamura, Takashi, Kawai, Sayo, Hamajima, Nobuyuki, Oze, Isao, Imaizumi, Takeshi, Turin, Tanvir Chowdhury, Suzuki, Sadao, Kheradmand, Motahare, Mikami, Haruo, Ohnaka, Keizo, Watanabe, Yoshiyuki, Arisawa, Kokichi, Kubo, Michiaki, Tanaka, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830885/
https://www.ncbi.nlm.nih.gov/pubmed/24288525
http://dx.doi.org/10.1155/2013/980471
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author Hishida, Asahi
Wakai, Kenji
Naito, Mariko
Tamura, Takashi
Kawai, Sayo
Hamajima, Nobuyuki
Oze, Isao
Imaizumi, Takeshi
Turin, Tanvir Chowdhury
Suzuki, Sadao
Kheradmand, Motahare
Mikami, Haruo
Ohnaka, Keizo
Watanabe, Yoshiyuki
Arisawa, Kokichi
Kubo, Michiaki
Tanaka, Hideo
author_facet Hishida, Asahi
Wakai, Kenji
Naito, Mariko
Tamura, Takashi
Kawai, Sayo
Hamajima, Nobuyuki
Oze, Isao
Imaizumi, Takeshi
Turin, Tanvir Chowdhury
Suzuki, Sadao
Kheradmand, Motahare
Mikami, Haruo
Ohnaka, Keizo
Watanabe, Yoshiyuki
Arisawa, Kokichi
Kubo, Michiaki
Tanaka, Hideo
author_sort Hishida, Asahi
collection PubMed
description Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross-sectional data of J-MICC (Japan Multi-Institutional Collaborative Cohort) Study. The subjects for this analysis were 3,285 men and women, aged 35–69 years, selected from J-MICC Study participants; genotyping was conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3–5 (defined as eGFR < 60 ml/min/1.73 m(2)). Participants with CKD accounted for 17.3% of the study population. When those with PPARD T-842C T/T were defined as reference, those with PPARD T-842C T/C and C/C demonstrated the OR for CKD of 1.26 (95%CI 1.04–1.53) and 1.31 (95%CI 0.83–2.06), respectively. There were no significant associations between the polymorphisms in other PPAR genes and the risk of CKD. The present study found a significantly increased risk of CKD in those with the C allele of PPARD T-842C, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.
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spelling pubmed-38308852013-11-28 Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study Hishida, Asahi Wakai, Kenji Naito, Mariko Tamura, Takashi Kawai, Sayo Hamajima, Nobuyuki Oze, Isao Imaizumi, Takeshi Turin, Tanvir Chowdhury Suzuki, Sadao Kheradmand, Motahare Mikami, Haruo Ohnaka, Keizo Watanabe, Yoshiyuki Arisawa, Kokichi Kubo, Michiaki Tanaka, Hideo PPAR Res Research Article Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross-sectional data of J-MICC (Japan Multi-Institutional Collaborative Cohort) Study. The subjects for this analysis were 3,285 men and women, aged 35–69 years, selected from J-MICC Study participants; genotyping was conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3–5 (defined as eGFR < 60 ml/min/1.73 m(2)). Participants with CKD accounted for 17.3% of the study population. When those with PPARD T-842C T/T were defined as reference, those with PPARD T-842C T/C and C/C demonstrated the OR for CKD of 1.26 (95%CI 1.04–1.53) and 1.31 (95%CI 0.83–2.06), respectively. There were no significant associations between the polymorphisms in other PPAR genes and the risk of CKD. The present study found a significantly increased risk of CKD in those with the C allele of PPARD T-842C, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future. Hindawi Publishing Corporation 2013 2013-11-07 /pmc/articles/PMC3830885/ /pubmed/24288525 http://dx.doi.org/10.1155/2013/980471 Text en Copyright © 2013 Asahi Hishida et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hishida, Asahi
Wakai, Kenji
Naito, Mariko
Tamura, Takashi
Kawai, Sayo
Hamajima, Nobuyuki
Oze, Isao
Imaizumi, Takeshi
Turin, Tanvir Chowdhury
Suzuki, Sadao
Kheradmand, Motahare
Mikami, Haruo
Ohnaka, Keizo
Watanabe, Yoshiyuki
Arisawa, Kokichi
Kubo, Michiaki
Tanaka, Hideo
Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study
title Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study
title_full Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study
title_fullStr Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study
title_full_unstemmed Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study
title_short Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study
title_sort polymorphisms in ppar genes (ppard, pparg, and ppargc1a) and the risk of chronic kidney disease in japanese: cross-sectional data from the j-micc study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830885/
https://www.ncbi.nlm.nih.gov/pubmed/24288525
http://dx.doi.org/10.1155/2013/980471
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