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Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study
Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830885/ https://www.ncbi.nlm.nih.gov/pubmed/24288525 http://dx.doi.org/10.1155/2013/980471 |
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author | Hishida, Asahi Wakai, Kenji Naito, Mariko Tamura, Takashi Kawai, Sayo Hamajima, Nobuyuki Oze, Isao Imaizumi, Takeshi Turin, Tanvir Chowdhury Suzuki, Sadao Kheradmand, Motahare Mikami, Haruo Ohnaka, Keizo Watanabe, Yoshiyuki Arisawa, Kokichi Kubo, Michiaki Tanaka, Hideo |
author_facet | Hishida, Asahi Wakai, Kenji Naito, Mariko Tamura, Takashi Kawai, Sayo Hamajima, Nobuyuki Oze, Isao Imaizumi, Takeshi Turin, Tanvir Chowdhury Suzuki, Sadao Kheradmand, Motahare Mikami, Haruo Ohnaka, Keizo Watanabe, Yoshiyuki Arisawa, Kokichi Kubo, Michiaki Tanaka, Hideo |
author_sort | Hishida, Asahi |
collection | PubMed |
description | Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross-sectional data of J-MICC (Japan Multi-Institutional Collaborative Cohort) Study. The subjects for this analysis were 3,285 men and women, aged 35–69 years, selected from J-MICC Study participants; genotyping was conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3–5 (defined as eGFR < 60 ml/min/1.73 m(2)). Participants with CKD accounted for 17.3% of the study population. When those with PPARD T-842C T/T were defined as reference, those with PPARD T-842C T/C and C/C demonstrated the OR for CKD of 1.26 (95%CI 1.04–1.53) and 1.31 (95%CI 0.83–2.06), respectively. There were no significant associations between the polymorphisms in other PPAR genes and the risk of CKD. The present study found a significantly increased risk of CKD in those with the C allele of PPARD T-842C, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future. |
format | Online Article Text |
id | pubmed-3830885 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38308852013-11-28 Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study Hishida, Asahi Wakai, Kenji Naito, Mariko Tamura, Takashi Kawai, Sayo Hamajima, Nobuyuki Oze, Isao Imaizumi, Takeshi Turin, Tanvir Chowdhury Suzuki, Sadao Kheradmand, Motahare Mikami, Haruo Ohnaka, Keizo Watanabe, Yoshiyuki Arisawa, Kokichi Kubo, Michiaki Tanaka, Hideo PPAR Res Research Article Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross-sectional data of J-MICC (Japan Multi-Institutional Collaborative Cohort) Study. The subjects for this analysis were 3,285 men and women, aged 35–69 years, selected from J-MICC Study participants; genotyping was conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3–5 (defined as eGFR < 60 ml/min/1.73 m(2)). Participants with CKD accounted for 17.3% of the study population. When those with PPARD T-842C T/T were defined as reference, those with PPARD T-842C T/C and C/C demonstrated the OR for CKD of 1.26 (95%CI 1.04–1.53) and 1.31 (95%CI 0.83–2.06), respectively. There were no significant associations between the polymorphisms in other PPAR genes and the risk of CKD. The present study found a significantly increased risk of CKD in those with the C allele of PPARD T-842C, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future. Hindawi Publishing Corporation 2013 2013-11-07 /pmc/articles/PMC3830885/ /pubmed/24288525 http://dx.doi.org/10.1155/2013/980471 Text en Copyright © 2013 Asahi Hishida et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hishida, Asahi Wakai, Kenji Naito, Mariko Tamura, Takashi Kawai, Sayo Hamajima, Nobuyuki Oze, Isao Imaizumi, Takeshi Turin, Tanvir Chowdhury Suzuki, Sadao Kheradmand, Motahare Mikami, Haruo Ohnaka, Keizo Watanabe, Yoshiyuki Arisawa, Kokichi Kubo, Michiaki Tanaka, Hideo Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study |
title | Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study |
title_full | Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study |
title_fullStr | Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study |
title_full_unstemmed | Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study |
title_short | Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study |
title_sort | polymorphisms in ppar genes (ppard, pparg, and ppargc1a) and the risk of chronic kidney disease in japanese: cross-sectional data from the j-micc study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830885/ https://www.ncbi.nlm.nih.gov/pubmed/24288525 http://dx.doi.org/10.1155/2013/980471 |
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