Gender Difference in Cisplatin-Induced Nephrotoxicity in a Rat Model: Greater Intensity of Damage in Male Than Female

BACKGROUND: Nephrotoxicity and hepatotoxicity are side effects of Cisplatin (CP) therapy. OBJECTIVES: We investigated the role of gender in CP-induced nephrotoxicity and hepatotoxicity. MATERIALS AND METHODS: Low dose of CP (1 mg/kg/day; ip) was administered daily to male and female Wistar rats for...

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Autores principales: Nematbakhsh, Mehdi, Ebrahimian, Shadi, Tooyserkani, Mona, Eshraghi-Jazi, Fatemeh, Talebi, Ardeshir, Ashrafi, Farzaneh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830908/
https://www.ncbi.nlm.nih.gov/pubmed/24282792
http://dx.doi.org/10.5812/numonthly.10128
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author Nematbakhsh, Mehdi
Ebrahimian, Shadi
Tooyserkani, Mona
Eshraghi-Jazi, Fatemeh
Talebi, Ardeshir
Ashrafi, Farzaneh
author_facet Nematbakhsh, Mehdi
Ebrahimian, Shadi
Tooyserkani, Mona
Eshraghi-Jazi, Fatemeh
Talebi, Ardeshir
Ashrafi, Farzaneh
author_sort Nematbakhsh, Mehdi
collection PubMed
description BACKGROUND: Nephrotoxicity and hepatotoxicity are side effects of Cisplatin (CP) therapy. OBJECTIVES: We investigated the role of gender in CP-induced nephrotoxicity and hepatotoxicity. MATERIALS AND METHODS: Low dose of CP (1 mg/kg/day; ip) was administered daily to male and female Wistar rats for 15 consecutive days. Serum creatinine (Cr), blood urea nitrogen (BUN), malondialdehyde (MDA), nitric oxide (NO) metabolite, and magnesium (Mg) levels were determined. RESULTS: The percentage of weight loss and the serum levels of MDA and nitrite in male and female animals were not statistically different. However, the serum levels of BUN, Cr, Mg, and kidney MDA levels, and kidney weight and damage score were significantly greater in males than in females (P < 0.05). CONCLUSIONS: CP-induced nephrotoxicity is gender related for which the mechanisms should be determined.
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spelling pubmed-38309082013-11-26 Gender Difference in Cisplatin-Induced Nephrotoxicity in a Rat Model: Greater Intensity of Damage in Male Than Female Nematbakhsh, Mehdi Ebrahimian, Shadi Tooyserkani, Mona Eshraghi-Jazi, Fatemeh Talebi, Ardeshir Ashrafi, Farzaneh Nephrourol Mon Research Article BACKGROUND: Nephrotoxicity and hepatotoxicity are side effects of Cisplatin (CP) therapy. OBJECTIVES: We investigated the role of gender in CP-induced nephrotoxicity and hepatotoxicity. MATERIALS AND METHODS: Low dose of CP (1 mg/kg/day; ip) was administered daily to male and female Wistar rats for 15 consecutive days. Serum creatinine (Cr), blood urea nitrogen (BUN), malondialdehyde (MDA), nitric oxide (NO) metabolite, and magnesium (Mg) levels were determined. RESULTS: The percentage of weight loss and the serum levels of MDA and nitrite in male and female animals were not statistically different. However, the serum levels of BUN, Cr, Mg, and kidney MDA levels, and kidney weight and damage score were significantly greater in males than in females (P < 0.05). CONCLUSIONS: CP-induced nephrotoxicity is gender related for which the mechanisms should be determined. Kowsar 2013-06-25 2013-07-01 /pmc/articles/PMC3830908/ /pubmed/24282792 http://dx.doi.org/10.5812/numonthly.10128 Text en Copyright © 2013, Nephrology and Urology Research Center http://creativecommons.org/licenses/by/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nematbakhsh, Mehdi
Ebrahimian, Shadi
Tooyserkani, Mona
Eshraghi-Jazi, Fatemeh
Talebi, Ardeshir
Ashrafi, Farzaneh
Gender Difference in Cisplatin-Induced Nephrotoxicity in a Rat Model: Greater Intensity of Damage in Male Than Female
title Gender Difference in Cisplatin-Induced Nephrotoxicity in a Rat Model: Greater Intensity of Damage in Male Than Female
title_full Gender Difference in Cisplatin-Induced Nephrotoxicity in a Rat Model: Greater Intensity of Damage in Male Than Female
title_fullStr Gender Difference in Cisplatin-Induced Nephrotoxicity in a Rat Model: Greater Intensity of Damage in Male Than Female
title_full_unstemmed Gender Difference in Cisplatin-Induced Nephrotoxicity in a Rat Model: Greater Intensity of Damage in Male Than Female
title_short Gender Difference in Cisplatin-Induced Nephrotoxicity in a Rat Model: Greater Intensity of Damage in Male Than Female
title_sort gender difference in cisplatin-induced nephrotoxicity in a rat model: greater intensity of damage in male than female
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830908/
https://www.ncbi.nlm.nih.gov/pubmed/24282792
http://dx.doi.org/10.5812/numonthly.10128
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