Combinational Targeting Offsets Antigen Escape and Enhances Effector Functions of Adoptively Transferred T Cells in Glioblastoma

Preclinical and early clinical studies have demonstrated that chimeric antigen receptor (CAR)-redirected T cells are highly promising in cancer therapy. We observed that targeting HER2 in a glioblastoma (GBM) cell line results in the emergence of HER2-null tumor cells that maintain the expression of...

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Detalles Bibliográficos
Autores principales: Hegde, Meenakshi, Corder, Amanda, Chow, Kevin KH, Mukherjee, Malini, Ashoori, Aidin, Kew, Yvonne, Zhang, Yi Jonathan, Baskin, David S, Merchant, Fatima A, Brawley, Vita S, Byrd, Tiara T, Krebs, Simone, Wu, Meng Fen, Liu, Hao, Heslop, Helen E, Gottachalk, Stephen, Yvon, Eric, Ahmed, Nabil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831041/
https://www.ncbi.nlm.nih.gov/pubmed/23939024
http://dx.doi.org/10.1038/mt.2013.185

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