Iron(II)-dependent dioxygenase and N-formylamide deformylase catalyze the reactions from 5-hydroxy-2-pyridone to maleamate

5-Hydroxy-2-pyridone (2,5-DHP) is a central metabolic intermediate in catabolism of many pyridine derivatives, and has been suggested as a potential carcinogen. 2,5-DHP is frequently transformed to N-formylmaleamic acid (NFM) by a 2,5-DHP dioxygenase. Three hypotheses were formerly discussed for con...

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Detalles Bibliográficos
Autores principales: Yao, Yuxiang, Tang, Hongzhi, Ren, Huixue, Yu, Hao, Wang, Lijuan, Zhang, Wei, Behrman, Edward J., Xu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831237/
https://www.ncbi.nlm.nih.gov/pubmed/24241081
http://dx.doi.org/10.1038/srep03235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831237/
https://www.ncbi.nlm.nih.gov/pubmed/24241081
http://dx.doi.org/10.1038/srep03235

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