Cargando…
Foveal slope measurements in subjects with high-risk of age-related macular degeneration
BACKGROUND: Recent reports indicated that the slope of the foveal depression influences the macular pigment (MP) spatial profile. MP has been shown to confer possible protection against age-related macular degeneration (ARMD) because of its antioxidant properties. AIMS: To study the configuration of...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831767/ https://www.ncbi.nlm.nih.gov/pubmed/24104710 http://dx.doi.org/10.4103/0301-4738.119437 |
_version_ | 1782291618480521216 |
---|---|
author | Raman, Rajiv Lahane, Sayalee Gupta, Aditi Sandeep, D Sharma, Tarun |
author_facet | Raman, Rajiv Lahane, Sayalee Gupta, Aditi Sandeep, D Sharma, Tarun |
author_sort | Raman, Rajiv |
collection | PubMed |
description | BACKGROUND: Recent reports indicated that the slope of the foveal depression influences the macular pigment (MP) spatial profile. MP has been shown to confer possible protection against age-related macular degeneration (ARMD) because of its antioxidant properties. AIMS: To study the configuration of foveal slope and the foveal thickness in fellow eyes of subjects with unilateral neovascular ARMD. SETTINGS AND DESIGN: Case-control series. MATERIALS AND METHODS: The study population consisted of 30 cases aged >50, who had unilateral choroidal neovascular membrane (CNVM) or disciform scar in the fellow eye and 29 controls aged >50, who had no sign of ARMD in the either eye. Using spectral-domain optical coherence tomography, foveal thickness at different locations including the central subfield foveal thickness (CSFT) was noted. The foveal slopes were calculated in the six radial scans (between 0.25° and 1° retinal eccentricity) as well as the 3D scan. RESULTS: Cases had a significantly higher CSFT when compared to controls (215.1 ± 36.19 μ vs. 193.0 ± 17.38 μ, P = 0.004). On the 3D scan, the cases had shallower superior (cases 1.32 ± 0.32 vs. controls 1.45 ± 0.13, P = 0.04) and temporal slopes (cases 1.27 ± 0.21 vs. controls 1.39 ± 0.12, P = 0.01) in comparison to the controls. CONCLUSIONS: We noted a shallower superior and temporal foveal slope and a higher CSFT in the fellow eyes of subjects with a unilateral neovascular ARMD. Prospective studies observing the development of CNVM in subjects with altered foveal slope might provide more information on this optical coherence tomography finding. |
format | Online Article Text |
id | pubmed-3831767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38317672013-12-03 Foveal slope measurements in subjects with high-risk of age-related macular degeneration Raman, Rajiv Lahane, Sayalee Gupta, Aditi Sandeep, D Sharma, Tarun Indian J Ophthalmol Original Article BACKGROUND: Recent reports indicated that the slope of the foveal depression influences the macular pigment (MP) spatial profile. MP has been shown to confer possible protection against age-related macular degeneration (ARMD) because of its antioxidant properties. AIMS: To study the configuration of foveal slope and the foveal thickness in fellow eyes of subjects with unilateral neovascular ARMD. SETTINGS AND DESIGN: Case-control series. MATERIALS AND METHODS: The study population consisted of 30 cases aged >50, who had unilateral choroidal neovascular membrane (CNVM) or disciform scar in the fellow eye and 29 controls aged >50, who had no sign of ARMD in the either eye. Using spectral-domain optical coherence tomography, foveal thickness at different locations including the central subfield foveal thickness (CSFT) was noted. The foveal slopes were calculated in the six radial scans (between 0.25° and 1° retinal eccentricity) as well as the 3D scan. RESULTS: Cases had a significantly higher CSFT when compared to controls (215.1 ± 36.19 μ vs. 193.0 ± 17.38 μ, P = 0.004). On the 3D scan, the cases had shallower superior (cases 1.32 ± 0.32 vs. controls 1.45 ± 0.13, P = 0.04) and temporal slopes (cases 1.27 ± 0.21 vs. controls 1.39 ± 0.12, P = 0.01) in comparison to the controls. CONCLUSIONS: We noted a shallower superior and temporal foveal slope and a higher CSFT in the fellow eyes of subjects with a unilateral neovascular ARMD. Prospective studies observing the development of CNVM in subjects with altered foveal slope might provide more information on this optical coherence tomography finding. Medknow Publications & Media Pvt Ltd 2013-09 /pmc/articles/PMC3831767/ /pubmed/24104710 http://dx.doi.org/10.4103/0301-4738.119437 Text en Copyright: © Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Raman, Rajiv Lahane, Sayalee Gupta, Aditi Sandeep, D Sharma, Tarun Foveal slope measurements in subjects with high-risk of age-related macular degeneration |
title | Foveal slope measurements in subjects with high-risk of age-related macular degeneration |
title_full | Foveal slope measurements in subjects with high-risk of age-related macular degeneration |
title_fullStr | Foveal slope measurements in subjects with high-risk of age-related macular degeneration |
title_full_unstemmed | Foveal slope measurements in subjects with high-risk of age-related macular degeneration |
title_short | Foveal slope measurements in subjects with high-risk of age-related macular degeneration |
title_sort | foveal slope measurements in subjects with high-risk of age-related macular degeneration |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831767/ https://www.ncbi.nlm.nih.gov/pubmed/24104710 http://dx.doi.org/10.4103/0301-4738.119437 |
work_keys_str_mv | AT ramanrajiv fovealslopemeasurementsinsubjectswithhighriskofagerelatedmaculardegeneration AT lahanesayalee fovealslopemeasurementsinsubjectswithhighriskofagerelatedmaculardegeneration AT guptaaditi fovealslopemeasurementsinsubjectswithhighriskofagerelatedmaculardegeneration AT sandeepd fovealslopemeasurementsinsubjectswithhighriskofagerelatedmaculardegeneration AT sharmatarun fovealslopemeasurementsinsubjectswithhighriskofagerelatedmaculardegeneration |