Cargando…

Cytotoxicity of Diimine Palladium (II) Complexes of Alkyldithiocarbamate Derivatives on Human Lung, Ovary and Liver Cells

Three new Complexes of formula [pd(bpy)(R-NH-CSS)] Cl (where bpy is 2/2′- bipyridine, and R-NH-CSS is butylamine, hexylamine- and octyamine-dithiocabamate anion) have been synthesized by University of Sistan and Blachostan. These complexes have been characterized by spectroscopic methods such as ult...

Descripción completa

Detalles Bibliográficos
Autores principales: Aryanpour, Narges, Mansouri-Torshizi, Hassan, Nakhjavan, Maryam, H. Shirazi, Farshad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832162/
https://www.ncbi.nlm.nih.gov/pubmed/24250494
_version_ 1782291645898686464
author Aryanpour, Narges
Mansouri-Torshizi, Hassan
Nakhjavan, Maryam
H. Shirazi, Farshad
author_facet Aryanpour, Narges
Mansouri-Torshizi, Hassan
Nakhjavan, Maryam
H. Shirazi, Farshad
author_sort Aryanpour, Narges
collection PubMed
description Three new Complexes of formula [pd(bpy)(R-NH-CSS)] Cl (where bpy is 2/2′- bipyridine, and R-NH-CSS is butylamine, hexylamine- and octyamine-dithiocabamate anion) have been synthesized by University of Sistan and Blachostan. These complexes have been characterized by spectroscopic methods such as ultraviolet-visible, infrared and (1)H-NMR as well as conductivity measurements and chemical analysis. In these complexes, each of the dithiocarbamate ligands coordinates to Pd (II) center as bidentate with two sulfur atoms. We have found a 1:1 electrolyte in water conductivity test for the above mentioned compounds. To measure the biologic activity and potential anticancer efficacy of these compounds, they have been compared with cisplatin and its palladium analogue of [Pd (NH(3))(2) Cl(2)] on three different cell lines of human hepatocarcinoma HepG2, human ovarian carcinoma OV2008, and human lung adenocarcinoma A549. Clonogenic assay has shown LD(50)s in the range of 0.131±0.025 to 0.934 ± 0.194 for these compounds on above cell lines. In comparison, cisplatin has shown LD(50)s of 0.838 ± 0.074, 2.196 ± 0.220, and 2.799 ± 0.733 on OV2008, HepG2 and A549 cell lines, respectively. As a conclusion, above three new complexes have shown higher cytotoxicities compared to cisplatin on three different human cell lines. Based on biological tests, these compounds may potentially be considered as good anticancer candidates for further pharmacological studies.
format Online
Article
Text
id pubmed-3832162
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Shaheed Beheshti University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-38321622013-11-18 Cytotoxicity of Diimine Palladium (II) Complexes of Alkyldithiocarbamate Derivatives on Human Lung, Ovary and Liver Cells Aryanpour, Narges Mansouri-Torshizi, Hassan Nakhjavan, Maryam H. Shirazi, Farshad Iran J Pharm Res Original Article Three new Complexes of formula [pd(bpy)(R-NH-CSS)] Cl (where bpy is 2/2′- bipyridine, and R-NH-CSS is butylamine, hexylamine- and octyamine-dithiocabamate anion) have been synthesized by University of Sistan and Blachostan. These complexes have been characterized by spectroscopic methods such as ultraviolet-visible, infrared and (1)H-NMR as well as conductivity measurements and chemical analysis. In these complexes, each of the dithiocarbamate ligands coordinates to Pd (II) center as bidentate with two sulfur atoms. We have found a 1:1 electrolyte in water conductivity test for the above mentioned compounds. To measure the biologic activity and potential anticancer efficacy of these compounds, they have been compared with cisplatin and its palladium analogue of [Pd (NH(3))(2) Cl(2)] on three different cell lines of human hepatocarcinoma HepG2, human ovarian carcinoma OV2008, and human lung adenocarcinoma A549. Clonogenic assay has shown LD(50)s in the range of 0.131±0.025 to 0.934 ± 0.194 for these compounds on above cell lines. In comparison, cisplatin has shown LD(50)s of 0.838 ± 0.074, 2.196 ± 0.220, and 2.799 ± 0.733 on OV2008, HepG2 and A549 cell lines, respectively. As a conclusion, above three new complexes have shown higher cytotoxicities compared to cisplatin on three different human cell lines. Based on biological tests, these compounds may potentially be considered as good anticancer candidates for further pharmacological studies. Shaheed Beheshti University of Medical Sciences 2012 /pmc/articles/PMC3832162/ /pubmed/24250494 Text en © 2012 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Aryanpour, Narges
Mansouri-Torshizi, Hassan
Nakhjavan, Maryam
H. Shirazi, Farshad
Cytotoxicity of Diimine Palladium (II) Complexes of Alkyldithiocarbamate Derivatives on Human Lung, Ovary and Liver Cells
title Cytotoxicity of Diimine Palladium (II) Complexes of Alkyldithiocarbamate Derivatives on Human Lung, Ovary and Liver Cells
title_full Cytotoxicity of Diimine Palladium (II) Complexes of Alkyldithiocarbamate Derivatives on Human Lung, Ovary and Liver Cells
title_fullStr Cytotoxicity of Diimine Palladium (II) Complexes of Alkyldithiocarbamate Derivatives on Human Lung, Ovary and Liver Cells
title_full_unstemmed Cytotoxicity of Diimine Palladium (II) Complexes of Alkyldithiocarbamate Derivatives on Human Lung, Ovary and Liver Cells
title_short Cytotoxicity of Diimine Palladium (II) Complexes of Alkyldithiocarbamate Derivatives on Human Lung, Ovary and Liver Cells
title_sort cytotoxicity of diimine palladium (ii) complexes of alkyldithiocarbamate derivatives on human lung, ovary and liver cells
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832162/
https://www.ncbi.nlm.nih.gov/pubmed/24250494
work_keys_str_mv AT aryanpournarges cytotoxicityofdiiminepalladiumiicomplexesofalkyldithiocarbamatederivativesonhumanlungovaryandlivercells
AT mansouritorshizihassan cytotoxicityofdiiminepalladiumiicomplexesofalkyldithiocarbamatederivativesonhumanlungovaryandlivercells
AT nakhjavanmaryam cytotoxicityofdiiminepalladiumiicomplexesofalkyldithiocarbamatederivativesonhumanlungovaryandlivercells
AT hshirazifarshad cytotoxicityofdiiminepalladiumiicomplexesofalkyldithiocarbamatederivativesonhumanlungovaryandlivercells