A Double-Blind, Placebo-Controlled Study of the Aqueous Extract of Echium amoenum for Patients with General Anxiety Disorder

The aim of this study was to assess the efficacy and tolerability of the aqueous extract of Echium amoenum in combination with SSRIs in patients with General Anxiety Disorder (GAD). The study was an 8-week double-blind randomized clinical trial. Thirty-seven adult outpatients who met the DSM-IV-TR c...

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Autores principales: Sayyah, Mehdi, Siahpoosh, Amir, Khalili, Hamidreza, Malayeri, Alireza, Samaee, Hamidreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832167/
https://www.ncbi.nlm.nih.gov/pubmed/24250495
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author Sayyah, Mehdi
Siahpoosh, Amir
Khalili, Hamidreza
Malayeri, Alireza
Samaee, Hamidreza
author_facet Sayyah, Mehdi
Siahpoosh, Amir
Khalili, Hamidreza
Malayeri, Alireza
Samaee, Hamidreza
author_sort Sayyah, Mehdi
collection PubMed
description The aim of this study was to assess the efficacy and tolerability of the aqueous extract of Echium amoenum in combination with SSRIs in patients with General Anxiety Disorder (GAD). The study was an 8-week double-blind randomized clinical trial. Thirty-seven adult outpatients who met the DSM-IV-TR criteria for GAD based on the structured clinical interview participated in the trial. In this study, patients were randomly assigned to receive the aqueous extract (500 mg) plus fluoxetine or fluoxetine (20 mg/day) plus placebo. The results showed significant difference between the two groups in the treatment of GAD. Moreover, there was not any significant difference between the two groups in terms of observed side effects. E. amoenum is effective on anxiety disorder, especially in higher dosage, without any serious side effects.
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spelling pubmed-38321672013-11-18 A Double-Blind, Placebo-Controlled Study of the Aqueous Extract of Echium amoenum for Patients with General Anxiety Disorder Sayyah, Mehdi Siahpoosh, Amir Khalili, Hamidreza Malayeri, Alireza Samaee, Hamidreza Iran J Pharm Res Original Article The aim of this study was to assess the efficacy and tolerability of the aqueous extract of Echium amoenum in combination with SSRIs in patients with General Anxiety Disorder (GAD). The study was an 8-week double-blind randomized clinical trial. Thirty-seven adult outpatients who met the DSM-IV-TR criteria for GAD based on the structured clinical interview participated in the trial. In this study, patients were randomly assigned to receive the aqueous extract (500 mg) plus fluoxetine or fluoxetine (20 mg/day) plus placebo. The results showed significant difference between the two groups in the treatment of GAD. Moreover, there was not any significant difference between the two groups in terms of observed side effects. E. amoenum is effective on anxiety disorder, especially in higher dosage, without any serious side effects. Shaheed Beheshti University of Medical Sciences 2012 /pmc/articles/PMC3832167/ /pubmed/24250495 Text en © 2012 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sayyah, Mehdi
Siahpoosh, Amir
Khalili, Hamidreza
Malayeri, Alireza
Samaee, Hamidreza
A Double-Blind, Placebo-Controlled Study of the Aqueous Extract of Echium amoenum for Patients with General Anxiety Disorder
title A Double-Blind, Placebo-Controlled Study of the Aqueous Extract of Echium amoenum for Patients with General Anxiety Disorder
title_full A Double-Blind, Placebo-Controlled Study of the Aqueous Extract of Echium amoenum for Patients with General Anxiety Disorder
title_fullStr A Double-Blind, Placebo-Controlled Study of the Aqueous Extract of Echium amoenum for Patients with General Anxiety Disorder
title_full_unstemmed A Double-Blind, Placebo-Controlled Study of the Aqueous Extract of Echium amoenum for Patients with General Anxiety Disorder
title_short A Double-Blind, Placebo-Controlled Study of the Aqueous Extract of Echium amoenum for Patients with General Anxiety Disorder
title_sort double-blind, placebo-controlled study of the aqueous extract of echium amoenum for patients with general anxiety disorder
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832167/
https://www.ncbi.nlm.nih.gov/pubmed/24250495
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