Metaplastic breast cancer: histologic characteristics, prognostic factors and systemic treatment strategies

Metaplastic breast cancer (MBC) is a rare subtype of invasive breast cancer that tends to have an aggressive clinical presentation as well as a variety of distinct histologic designations. Few systemic treatment options are available for MBC, as it has consistently shown a suboptimal response to sta...

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Autores principales: Schwartz, Theresa L, Mogal, Harveshp, Papageorgiou, Christos, Veerapong, Jula, Hsueh, Eddy C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832232/
https://www.ncbi.nlm.nih.gov/pubmed/24499560
http://dx.doi.org/10.1186/2162-3619-2-31
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author Schwartz, Theresa L
Mogal, Harveshp
Papageorgiou, Christos
Veerapong, Jula
Hsueh, Eddy C
author_facet Schwartz, Theresa L
Mogal, Harveshp
Papageorgiou, Christos
Veerapong, Jula
Hsueh, Eddy C
author_sort Schwartz, Theresa L
collection PubMed
description Metaplastic breast cancer (MBC) is a rare subtype of invasive breast cancer that tends to have an aggressive clinical presentation as well as a variety of distinct histologic designations. Few systemic treatment options are available for MBC, as it has consistently shown a suboptimal response to standard chemotherapy regimens. These characteristics result in a worse overall prognosis for patients with MBC compared to those with standard invasive breast cancer. Due to its rarity, data focusing on MBC is limited. This review will discuss the clinical presentation, breast imaging findings, histologic and molecular characteristics of MBC as well as potential future research directions.
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spelling pubmed-38322322013-11-19 Metaplastic breast cancer: histologic characteristics, prognostic factors and systemic treatment strategies Schwartz, Theresa L Mogal, Harveshp Papageorgiou, Christos Veerapong, Jula Hsueh, Eddy C Exp Hematol Oncol Review Metaplastic breast cancer (MBC) is a rare subtype of invasive breast cancer that tends to have an aggressive clinical presentation as well as a variety of distinct histologic designations. Few systemic treatment options are available for MBC, as it has consistently shown a suboptimal response to standard chemotherapy regimens. These characteristics result in a worse overall prognosis for patients with MBC compared to those with standard invasive breast cancer. Due to its rarity, data focusing on MBC is limited. This review will discuss the clinical presentation, breast imaging findings, histologic and molecular characteristics of MBC as well as potential future research directions. BioMed Central 2013-11-14 /pmc/articles/PMC3832232/ /pubmed/24499560 http://dx.doi.org/10.1186/2162-3619-2-31 Text en Copyright © 2013 Schwartz et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Schwartz, Theresa L
Mogal, Harveshp
Papageorgiou, Christos
Veerapong, Jula
Hsueh, Eddy C
Metaplastic breast cancer: histologic characteristics, prognostic factors and systemic treatment strategies
title Metaplastic breast cancer: histologic characteristics, prognostic factors and systemic treatment strategies
title_full Metaplastic breast cancer: histologic characteristics, prognostic factors and systemic treatment strategies
title_fullStr Metaplastic breast cancer: histologic characteristics, prognostic factors and systemic treatment strategies
title_full_unstemmed Metaplastic breast cancer: histologic characteristics, prognostic factors and systemic treatment strategies
title_short Metaplastic breast cancer: histologic characteristics, prognostic factors and systemic treatment strategies
title_sort metaplastic breast cancer: histologic characteristics, prognostic factors and systemic treatment strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832232/
https://www.ncbi.nlm.nih.gov/pubmed/24499560
http://dx.doi.org/10.1186/2162-3619-2-31
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