Protective Properties of Radio-Chemoresistant Glioblastoma Stem Cell Clones Are Associated with Metabolic Adaptation to Reduced Glucose Dependence

Glioblastoma stem cells (GSC) are a significant cell model for explaining brain tumor recurrence. However, mechanisms underlying their radiochemoresistance remain obscure. Here we show that most clonogenic cells in GSC cultures are sensitive to radiation treatment (RT) with or without temozolomide (...

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Detalles Bibliográficos
Autores principales: Ye, Fei, Zhang, Yibei, Liu, Yue, Yamada, Kazunari, Tso, Jonathan L., Menjivar, Jimmy C., Tian, Jane Y., Yong, William H., Schaue, Dörthe, Mischel, Paul S., Cloughesy, Timothy F., Nelson, Stanley F., Liau, Linda M., McBride, William, Tso, Cho-Lea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832364/
https://www.ncbi.nlm.nih.gov/pubmed/24260384
http://dx.doi.org/10.1371/journal.pone.0080397

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