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Targeting Eukaryotic Translation in Mesothelioma Cells with an eIF4E-Specific Antisense Oligonucleotide

BACKGROUND: Aberrant cap-dependent translation is implicated in tumorigenesis in multiple tumor types including mesothelioma. In this study, disabling the eIF4F complex by targeting eIF4E with eIF4E-specific antisense oligonucleotide (4EASO) is assessed as a therapy for mesothelioma. METHODS: Mesoth...

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Detalles Bibliográficos
Autores principales:	Jacobson, Blake A., Thumma, Saritha C., Jay-Dixon, Joseph, Patel, Manish R., Dubear Kroening, K., Kratzke, Marian G., Etchison, Ryan G., Konicek, Bruce W., Graff, Jeremy R., Kratzke, Robert A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832430/ https://www.ncbi.nlm.nih.gov/pubmed/24260583 http://dx.doi.org/10.1371/journal.pone.0081669

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