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No Association between Antenatal Common Mental Disorders in Low-Obstetric Risk Women and Adverse Birth Outcomes in Their Offspring: Results from the CDS Study in Ghana and Côte D'Ivoire

BACKGROUND: Evidence linking common mental disorders (CMD) in pregnant women to adverse birth outcomes is inconsistent, and studies often failed to control for pregnancy complications. This study aimed to explore the association between antenatal depression and anxiety symptoms and birth outcomes in...

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Autores principales: Bindt, Carola, Guo, Nan, Bonle, Marguerite Te, Appiah-Poku, John, Hinz, Rebecca, Barthel, Dana, Schoppen, Stefanie, Feldt, Torsten, Barkmann, Claus, Koffi, Mathurin, Loag, Wibke, Nguah, Samuel Blay, Eberhardt, Kirsten A., Tagbor, Harry, N’Goran, Eliezer, Ehrhardt, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832471/
https://www.ncbi.nlm.nih.gov/pubmed/24260460
http://dx.doi.org/10.1371/journal.pone.0080711
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author Bindt, Carola
Guo, Nan
Bonle, Marguerite Te
Appiah-Poku, John
Hinz, Rebecca
Barthel, Dana
Schoppen, Stefanie
Feldt, Torsten
Barkmann, Claus
Koffi, Mathurin
Loag, Wibke
Nguah, Samuel Blay
Eberhardt, Kirsten A.
Tagbor, Harry
N’Goran, Eliezer
Ehrhardt, Stephan
author_facet Bindt, Carola
Guo, Nan
Bonle, Marguerite Te
Appiah-Poku, John
Hinz, Rebecca
Barthel, Dana
Schoppen, Stefanie
Feldt, Torsten
Barkmann, Claus
Koffi, Mathurin
Loag, Wibke
Nguah, Samuel Blay
Eberhardt, Kirsten A.
Tagbor, Harry
N’Goran, Eliezer
Ehrhardt, Stephan
author_sort Bindt, Carola
collection PubMed
description BACKGROUND: Evidence linking common mental disorders (CMD) in pregnant women to adverse birth outcomes is inconsistent, and studies often failed to control for pregnancy complications. This study aimed to explore the association between antenatal depression and anxiety symptoms and birth outcomes in a low-obstetric risk sample of mother/child dyads in Ghana and Côte d’Ivoire. METHODS: In 2010-2011, a prospective cohort of 1030 women in their third trimester in Ghana and Côte d’Ivoire was enrolled. Depression and anxiety were assessed in the third trimester using the Patient Health Questionnaire depression module and the 7-item Generalized Anxiety Disorder scale. 719 mother/child dyads were included in the analysis. We constructed multivariate regression models to estimate the association between CMD and low birth weight (LBW), and preterm birth (PTB) to control for potential confounders. RESULTS: The prevalence of depression and anxiety symptoms were 28.9% and 14.2% respectively. The mean birth weight was 3172.1g (SD 440.6) and the prevalence of LBW was 1.7%. The mean gestational age was 39.6 weeks and the proportion of PTB was 4%. Multivariate linear regression revealed no significant association between maternal depression (B=52.2, 95% CI -18.2 122.6, p=0.15) or anxiety (B=17.1, 95% CI -74.6 108.7, p=0.72) and birth weight. Yet, low socio-economic status, female sex of the child, and younger maternal age were associated with lower birth weight. Multivariate logistic regression suggested no significant association between maternal depression (OR: 2.1, 95% CI 0.8 5.6, p=0.15) or anxiety (OR: 1.8, 95% CI 0.6 5.5, p=0.29) with PTB. CONCLUSIONS: Our data suggests that depression and/or anxiety in the 3(rd) trimester of pregnancy are not independent predictors of adverse birth outcomes in low obstetric risk women. The role of pregnancy complications as confounders or effect modifiers in studies of maternal CMD and their impact on birth outcomes should be investigated.
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spelling pubmed-38324712013-11-20 No Association between Antenatal Common Mental Disorders in Low-Obstetric Risk Women and Adverse Birth Outcomes in Their Offspring: Results from the CDS Study in Ghana and Côte D'Ivoire Bindt, Carola Guo, Nan Bonle, Marguerite Te Appiah-Poku, John Hinz, Rebecca Barthel, Dana Schoppen, Stefanie Feldt, Torsten Barkmann, Claus Koffi, Mathurin Loag, Wibke Nguah, Samuel Blay Eberhardt, Kirsten A. Tagbor, Harry N’Goran, Eliezer Ehrhardt, Stephan PLoS One Research Article BACKGROUND: Evidence linking common mental disorders (CMD) in pregnant women to adverse birth outcomes is inconsistent, and studies often failed to control for pregnancy complications. This study aimed to explore the association between antenatal depression and anxiety symptoms and birth outcomes in a low-obstetric risk sample of mother/child dyads in Ghana and Côte d’Ivoire. METHODS: In 2010-2011, a prospective cohort of 1030 women in their third trimester in Ghana and Côte d’Ivoire was enrolled. Depression and anxiety were assessed in the third trimester using the Patient Health Questionnaire depression module and the 7-item Generalized Anxiety Disorder scale. 719 mother/child dyads were included in the analysis. We constructed multivariate regression models to estimate the association between CMD and low birth weight (LBW), and preterm birth (PTB) to control for potential confounders. RESULTS: The prevalence of depression and anxiety symptoms were 28.9% and 14.2% respectively. The mean birth weight was 3172.1g (SD 440.6) and the prevalence of LBW was 1.7%. The mean gestational age was 39.6 weeks and the proportion of PTB was 4%. Multivariate linear regression revealed no significant association between maternal depression (B=52.2, 95% CI -18.2 122.6, p=0.15) or anxiety (B=17.1, 95% CI -74.6 108.7, p=0.72) and birth weight. Yet, low socio-economic status, female sex of the child, and younger maternal age were associated with lower birth weight. Multivariate logistic regression suggested no significant association between maternal depression (OR: 2.1, 95% CI 0.8 5.6, p=0.15) or anxiety (OR: 1.8, 95% CI 0.6 5.5, p=0.29) with PTB. CONCLUSIONS: Our data suggests that depression and/or anxiety in the 3(rd) trimester of pregnancy are not independent predictors of adverse birth outcomes in low obstetric risk women. The role of pregnancy complications as confounders or effect modifiers in studies of maternal CMD and their impact on birth outcomes should be investigated. Public Library of Science 2013-11-18 /pmc/articles/PMC3832471/ /pubmed/24260460 http://dx.doi.org/10.1371/journal.pone.0080711 Text en © 2013 Bindt et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Bindt, Carola
Guo, Nan
Bonle, Marguerite Te
Appiah-Poku, John
Hinz, Rebecca
Barthel, Dana
Schoppen, Stefanie
Feldt, Torsten
Barkmann, Claus
Koffi, Mathurin
Loag, Wibke
Nguah, Samuel Blay
Eberhardt, Kirsten A.
Tagbor, Harry
N’Goran, Eliezer
Ehrhardt, Stephan
No Association between Antenatal Common Mental Disorders in Low-Obstetric Risk Women and Adverse Birth Outcomes in Their Offspring: Results from the CDS Study in Ghana and Côte D'Ivoire
title No Association between Antenatal Common Mental Disorders in Low-Obstetric Risk Women and Adverse Birth Outcomes in Their Offspring: Results from the CDS Study in Ghana and Côte D'Ivoire
title_full No Association between Antenatal Common Mental Disorders in Low-Obstetric Risk Women and Adverse Birth Outcomes in Their Offspring: Results from the CDS Study in Ghana and Côte D'Ivoire
title_fullStr No Association between Antenatal Common Mental Disorders in Low-Obstetric Risk Women and Adverse Birth Outcomes in Their Offspring: Results from the CDS Study in Ghana and Côte D'Ivoire
title_full_unstemmed No Association between Antenatal Common Mental Disorders in Low-Obstetric Risk Women and Adverse Birth Outcomes in Their Offspring: Results from the CDS Study in Ghana and Côte D'Ivoire
title_short No Association between Antenatal Common Mental Disorders in Low-Obstetric Risk Women and Adverse Birth Outcomes in Their Offspring: Results from the CDS Study in Ghana and Côte D'Ivoire
title_sort no association between antenatal common mental disorders in low-obstetric risk women and adverse birth outcomes in their offspring: results from the cds study in ghana and côte d'ivoire
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832471/
https://www.ncbi.nlm.nih.gov/pubmed/24260460
http://dx.doi.org/10.1371/journal.pone.0080711
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