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Validity of Fecal Occult Blood Test in the National Cancer Screening Program, Korea

AIM: The aims of the current study were to assess the validity of the fecal occult blood test (FOBT) in an organized screening setting in Korea and to determine factors associated with FOBT validity, such as screening round, age group, and anatomical location of the cancer. METHODS: Study participan...

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Autores principales: Shin, Aesun, Choi, Kui Son, Jun, Jae Kwan, Noh, Dai Keun, Suh, Mina, Jung, Kyu-Won, Kim, Byung Chang, Oh, Jae Hwan, Park, Eun-Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832630/
https://www.ncbi.nlm.nih.gov/pubmed/24260189
http://dx.doi.org/10.1371/journal.pone.0079292
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author Shin, Aesun
Choi, Kui Son
Jun, Jae Kwan
Noh, Dai Keun
Suh, Mina
Jung, Kyu-Won
Kim, Byung Chang
Oh, Jae Hwan
Park, Eun-Cheol
author_facet Shin, Aesun
Choi, Kui Son
Jun, Jae Kwan
Noh, Dai Keun
Suh, Mina
Jung, Kyu-Won
Kim, Byung Chang
Oh, Jae Hwan
Park, Eun-Cheol
author_sort Shin, Aesun
collection PubMed
description AIM: The aims of the current study were to assess the validity of the fecal occult blood test (FOBT) in an organized screening setting in Korea and to determine factors associated with FOBT validity, such as screening round, age group, and anatomical location of the cancer. METHODS: Study participants were those who were 50 years and older who received an FOBT through the National Cancer Screening Program between 2004 and 2007. Colorectal cancer diagnoses were ascertained through linkage with the Korean National Cancer Incidence Database. The positivity rate, colorectal cancer detection rate, interval cancer rate, sensitivity, specificity, and positive predictive value of the FOBT were calculated. RESULTS: A total of 2,193,093 tests were included in the analysis. Overall, the sensitivity of the FOBT for colorectal cancer was 59.7% for the first round and 56.1% for the subsequent round. Sensitivity was highest for distal colon cancer (65.9%) in the first round, and for rectal cancer (58.4%) for the subsequent round. The sensitivity and positive predictive value of the FOBT generally improved between 2004 and 2008. CONCLUSIONS: The FOBT showed reasonable validity in an organized screening setting, and the validity of the FOBT varied by screening round, anatomical location, and screening year.
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spelling pubmed-38326302013-11-20 Validity of Fecal Occult Blood Test in the National Cancer Screening Program, Korea Shin, Aesun Choi, Kui Son Jun, Jae Kwan Noh, Dai Keun Suh, Mina Jung, Kyu-Won Kim, Byung Chang Oh, Jae Hwan Park, Eun-Cheol PLoS One Research Article AIM: The aims of the current study were to assess the validity of the fecal occult blood test (FOBT) in an organized screening setting in Korea and to determine factors associated with FOBT validity, such as screening round, age group, and anatomical location of the cancer. METHODS: Study participants were those who were 50 years and older who received an FOBT through the National Cancer Screening Program between 2004 and 2007. Colorectal cancer diagnoses were ascertained through linkage with the Korean National Cancer Incidence Database. The positivity rate, colorectal cancer detection rate, interval cancer rate, sensitivity, specificity, and positive predictive value of the FOBT were calculated. RESULTS: A total of 2,193,093 tests were included in the analysis. Overall, the sensitivity of the FOBT for colorectal cancer was 59.7% for the first round and 56.1% for the subsequent round. Sensitivity was highest for distal colon cancer (65.9%) in the first round, and for rectal cancer (58.4%) for the subsequent round. The sensitivity and positive predictive value of the FOBT generally improved between 2004 and 2008. CONCLUSIONS: The FOBT showed reasonable validity in an organized screening setting, and the validity of the FOBT varied by screening round, anatomical location, and screening year. Public Library of Science 2013-11-08 /pmc/articles/PMC3832630/ /pubmed/24260189 http://dx.doi.org/10.1371/journal.pone.0079292 Text en © 2013 Shin et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Shin, Aesun
Choi, Kui Son
Jun, Jae Kwan
Noh, Dai Keun
Suh, Mina
Jung, Kyu-Won
Kim, Byung Chang
Oh, Jae Hwan
Park, Eun-Cheol
Validity of Fecal Occult Blood Test in the National Cancer Screening Program, Korea
title Validity of Fecal Occult Blood Test in the National Cancer Screening Program, Korea
title_full Validity of Fecal Occult Blood Test in the National Cancer Screening Program, Korea
title_fullStr Validity of Fecal Occult Blood Test in the National Cancer Screening Program, Korea
title_full_unstemmed Validity of Fecal Occult Blood Test in the National Cancer Screening Program, Korea
title_short Validity of Fecal Occult Blood Test in the National Cancer Screening Program, Korea
title_sort validity of fecal occult blood test in the national cancer screening program, korea
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832630/
https://www.ncbi.nlm.nih.gov/pubmed/24260189
http://dx.doi.org/10.1371/journal.pone.0079292
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