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Identification of regulatory structure and kinetic parameters of biochemical networks via mixed-integer dynamic optimization
BACKGROUND: Recovering the network topology and associated kinetic parameter values from time-series data are central topics in systems biology. Nevertheless, methods that simultaneously do both are few and lack generality. RESULTS: Here, we present a rigorous approach for simultaneously estimating...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832746/ https://www.ncbi.nlm.nih.gov/pubmed/24176044 http://dx.doi.org/10.1186/1752-0509-7-113 |