The osteocalcin gene rs1800247 polymorphism in Kashubian population

Osteocalcin is the most important noncollagenous protein component of the bone. Polymorphisms of osteocalcin gene were reported to be associated with bone mineral density. However, this relation was only confirmed in some populations. In this study presence of C/T polymorphism in osteocalcin gene (r...

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Detalles Bibliográficos
Autores principales: Specjalski, Krzysztof, Porzezińska, Maria, Siemińska, Alicja, Słomiński, Jan M., Jassem, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2012
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832755/
https://www.ncbi.nlm.nih.gov/pubmed/23233116
http://dx.doi.org/10.1007/s00296-012-2575-1
Descripción
Sumario:Osteocalcin is the most important noncollagenous protein component of the bone. Polymorphisms of osteocalcin gene were reported to be associated with bone mineral density. However, this relation was only confirmed in some populations. In this study presence of C/T polymorphism in osteocalcin gene (rs1800247) was determined in Kashubian population (northern Poland). The frequencies of variants were CC 9 %, TC 31 %, and TT 60 %, with no significant differences between genders. The genotypes were in Hardy–Weinberg equilibrium.

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