The osteocalcin gene rs1800247 polymorphism in Kashubian population

Osteocalcin is the most important noncollagenous protein component of the bone. Polymorphisms of osteocalcin gene were reported to be associated with bone mineral density. However, this relation was only confirmed in some populations. In this study presence of C/T polymorphism in osteocalcin gene (r...

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Autores principales: Specjalski, Krzysztof, Porzezińska, Maria, Siemińska, Alicja, Słomiński, Jan M., Jassem, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2012
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832755/
https://www.ncbi.nlm.nih.gov/pubmed/23233116
http://dx.doi.org/10.1007/s00296-012-2575-1
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author Specjalski, Krzysztof
Porzezińska, Maria
Siemińska, Alicja
Słomiński, Jan M.
Jassem, Ewa
author_facet Specjalski, Krzysztof
Porzezińska, Maria
Siemińska, Alicja
Słomiński, Jan M.
Jassem, Ewa
author_sort Specjalski, Krzysztof
collection PubMed
description Osteocalcin is the most important noncollagenous protein component of the bone. Polymorphisms of osteocalcin gene were reported to be associated with bone mineral density. However, this relation was only confirmed in some populations. In this study presence of C/T polymorphism in osteocalcin gene (rs1800247) was determined in Kashubian population (northern Poland). The frequencies of variants were CC 9 %, TC 31 %, and TT 60 %, with no significant differences between genders. The genotypes were in Hardy–Weinberg equilibrium.
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spelling pubmed-38327552013-11-29 The osteocalcin gene rs1800247 polymorphism in Kashubian population Specjalski, Krzysztof Porzezińska, Maria Siemińska, Alicja Słomiński, Jan M. Jassem, Ewa Rheumatol Int Short Communication Osteocalcin is the most important noncollagenous protein component of the bone. Polymorphisms of osteocalcin gene were reported to be associated with bone mineral density. However, this relation was only confirmed in some populations. In this study presence of C/T polymorphism in osteocalcin gene (rs1800247) was determined in Kashubian population (northern Poland). The frequencies of variants were CC 9 %, TC 31 %, and TT 60 %, with no significant differences between genders. The genotypes were in Hardy–Weinberg equilibrium. Springer Berlin Heidelberg 2012-12-12 2013 /pmc/articles/PMC3832755/ /pubmed/23233116 http://dx.doi.org/10.1007/s00296-012-2575-1 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Short Communication
Specjalski, Krzysztof
Porzezińska, Maria
Siemińska, Alicja
Słomiński, Jan M.
Jassem, Ewa
The osteocalcin gene rs1800247 polymorphism in Kashubian population
title The osteocalcin gene rs1800247 polymorphism in Kashubian population
title_full The osteocalcin gene rs1800247 polymorphism in Kashubian population
title_fullStr The osteocalcin gene rs1800247 polymorphism in Kashubian population
title_full_unstemmed The osteocalcin gene rs1800247 polymorphism in Kashubian population
title_short The osteocalcin gene rs1800247 polymorphism in Kashubian population
title_sort osteocalcin gene rs1800247 polymorphism in kashubian population
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832755/
https://www.ncbi.nlm.nih.gov/pubmed/23233116
http://dx.doi.org/10.1007/s00296-012-2575-1
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