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Heart rate variability in overactive bladder experimental model
INTRODUCTION: Two main pathophysiological concepts of overactive bladder (OAB) are postulated: the neurogenic and myogenic theories. Autonomic nervous system (ANS) dysfunction is also involved in OAB pathophysiology. The purpose of our study was to estimate ANS activity by heart rate variability (HR...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832811/ https://www.ncbi.nlm.nih.gov/pubmed/24273581 http://dx.doi.org/10.5114/aoms.2012.30946 |
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author | Dobrek, Łukasz Thor, Piotr |
author_facet | Dobrek, Łukasz Thor, Piotr |
author_sort | Dobrek, Łukasz |
collection | PubMed |
description | INTRODUCTION: Two main pathophysiological concepts of overactive bladder (OAB) are postulated: the neurogenic and myogenic theories. Autonomic nervous system (ANS) dysfunction is also involved in OAB pathophysiology. The purpose of our study was to estimate ANS activity by heart rate variability (HRV) assessment in two OAB experimental models evoked by cyclophosphamide administration: acute (AOAB) and chronic (COAB) overactive ones. MATERIAL AND METHODS: In the AOAB model, an i.p. dose of cyclophosphamide was administered (200 mg/kg body weight) while the COAB model received 4 times the i.p. administration of cyclophosphamide (75 mg/kg body weight). In each subject, after urethane anaesthesia (1.2 g/kg body weight), 20-minute ECG recordings (PowerLab) were performed with subsequent HRV analysis. RESULTS: Most of the differences in time domain analysis parameters were insignificant, except those concerning SDNN and rMSSD (p < 0.05). In frequency analysis, a power decrease of all standard spectral components was revealed in both OAB groups. In AOAB, TP (1.43 ±1.21 vs. 7.92 ±6.22 in control; p < 0.05) and VLF (0.95 ±1.08 vs. 6.97 ±5.99 in control; p < 0.05) showed significant power decrease, whereas the COAB group was mostly characterized by LF (0.09 ±0.15 vs. 0.34 ±0.33 in control; p < 0.05) and HF (0.25 ±0.29 vs. 0.60 ±0.41 in control; p < 0.05) decrease. CONCLUSIONS: The ANS disturbances, found as standard spectral parameter abnormalities, were demonstrated in both AOAB and COAB. When this finding is analysed, together with the lack of statistically significant differences in normalized nLF and nHF powers, the VLF changes seem to play an essential role, probably reflecting the progression in bladder inflammatory changes. |
format | Online Article Text |
id | pubmed-3832811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-38328112013-11-22 Heart rate variability in overactive bladder experimental model Dobrek, Łukasz Thor, Piotr Arch Med Sci Experimental Research INTRODUCTION: Two main pathophysiological concepts of overactive bladder (OAB) are postulated: the neurogenic and myogenic theories. Autonomic nervous system (ANS) dysfunction is also involved in OAB pathophysiology. The purpose of our study was to estimate ANS activity by heart rate variability (HRV) assessment in two OAB experimental models evoked by cyclophosphamide administration: acute (AOAB) and chronic (COAB) overactive ones. MATERIAL AND METHODS: In the AOAB model, an i.p. dose of cyclophosphamide was administered (200 mg/kg body weight) while the COAB model received 4 times the i.p. administration of cyclophosphamide (75 mg/kg body weight). In each subject, after urethane anaesthesia (1.2 g/kg body weight), 20-minute ECG recordings (PowerLab) were performed with subsequent HRV analysis. RESULTS: Most of the differences in time domain analysis parameters were insignificant, except those concerning SDNN and rMSSD (p < 0.05). In frequency analysis, a power decrease of all standard spectral components was revealed in both OAB groups. In AOAB, TP (1.43 ±1.21 vs. 7.92 ±6.22 in control; p < 0.05) and VLF (0.95 ±1.08 vs. 6.97 ±5.99 in control; p < 0.05) showed significant power decrease, whereas the COAB group was mostly characterized by LF (0.09 ±0.15 vs. 0.34 ±0.33 in control; p < 0.05) and HF (0.25 ±0.29 vs. 0.60 ±0.41 in control; p < 0.05) decrease. CONCLUSIONS: The ANS disturbances, found as standard spectral parameter abnormalities, were demonstrated in both AOAB and COAB. When this finding is analysed, together with the lack of statistically significant differences in normalized nLF and nHF powers, the VLF changes seem to play an essential role, probably reflecting the progression in bladder inflammatory changes. Termedia Publishing House 2012-10-08 2013-10-31 /pmc/articles/PMC3832811/ /pubmed/24273581 http://dx.doi.org/10.5114/aoms.2012.30946 Text en Copyright © 2013 Termedia & Banach http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Experimental Research Dobrek, Łukasz Thor, Piotr Heart rate variability in overactive bladder experimental model |
title | Heart rate variability in overactive bladder experimental model |
title_full | Heart rate variability in overactive bladder experimental model |
title_fullStr | Heart rate variability in overactive bladder experimental model |
title_full_unstemmed | Heart rate variability in overactive bladder experimental model |
title_short | Heart rate variability in overactive bladder experimental model |
title_sort | heart rate variability in overactive bladder experimental model |
topic | Experimental Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832811/ https://www.ncbi.nlm.nih.gov/pubmed/24273581 http://dx.doi.org/10.5114/aoms.2012.30946 |
work_keys_str_mv | AT dobrekłukasz heartratevariabilityinoveractivebladderexperimentalmodel AT thorpiotr heartratevariabilityinoveractivebladderexperimentalmodel |