Cargando…

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1 locus that possesses the shared susceptibility epitope (SE) and the citrullination of self-antigens. We show how citrullinated aggrecan and vimentin epitopes bind to HLA-DRB1*04:01/04. Citrulline was accommo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scally, Stephen W., Petersen, Jan, Law, Soi Cheng, Dudek, Nadine L., Nel, Hendrik J., Loh, Khai Lee, Wijeyewickrema, Lakshmi C., Eckle, Sidonia B.G., van Heemst, Jurgen, Pike, Robert N., McCluskey, James, Toes, Rene E., La Gruta, Nicole L., Purcell, Anthony W., Reid, Hugh H., Thomas, Ranjeny, Rossjohn, Jamie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832918/ https://www.ncbi.nlm.nih.gov/pubmed/24190431 http://dx.doi.org/10.1084/jem.20131241

Ejemplares similares

T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles
por: Law, Soi Cheng, et al.
Publicado: (2012)

Quantitative affinity measurement of small molecule ligand binding to major histocompatibility complex class-I–related protein 1 MR1
por: Wang, Carl J.H., et al.
Publicado: (2022)

Anti-citrullinated fibronectin antibodies in rheumatoid arthritis are associated with human leukocyte antigen-DRB1 shared epitope alleles
por: van Beers, Joyce JBC, et al.
Publicado: (2012)

Flow Cytometric Clinical Immunomonitoring Using Peptide–MHC Class II Tetramers: Optimization of Methods and Protocol Development
por: Jansen, Diahann T. S. L., et al.
Publicado: (2018)

The increased ability to present citrullinated peptides is not unique to HLA-SE molecules: arginine-to-citrulline conversion also enhances peptide affinity for HLA-DQ molecules
por: Kampstra, Arieke S. B., et al.
Publicado: (2016)

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers
por: Rahimpour, Azad, et al.
Publicado: (2015)

Abs No: HLA-A*31:01 positive hypersensitive patient
por: Lichtenfels, Maike, et al.
Publicado: (2014)

A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells
por: Eckle, Sidonia B.G., et al.
Publicado: (2014)

The molecular bases of δ/αβ T cell–mediated antigen recognition
por: Pellicci, Daniel G., et al.
Publicado: (2014)

The Role of the Lys628 (192) Residue of the Complement Protease, C1s, in Interacting with Peptide and Protein Substrates
por: Wijeyewickrema, Lakshmi Carmel, et al.
Publicado: (2014)

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells
por: Reantragoon, Rangsima, et al.
Publicado: (2013)

Using mass spectrometry to monitor drug induced changes in antigen presentation by the human leukocyte antigen
por: Illing, Patricia, et al.
Publicado: (2014)

HLA-DRB1 Genotypes and the Risk of Developing Anti Citrullinated Protein Antibody (ACPA) Positive Rheumatoid Arthritis
por: Balandraud, Nathalie, et al.
Publicado: (2013)

Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor
por: Balsa, Alejandro, et al.
Publicado: (2010)

Association of human leukocyte antigen-DRB1 with anti-cyclic citrullinated peptide autoantibodies in Saudi patients with rheumatoid arthritis
por: Alrogy, Abdullah, et al.
Publicado: (2017)

Biased MAIT TCR Usage Poised for Limited Antigen Diversity?
por: Souter, Michael N. T., et al.
Publicado: (2020)

RE: Association of human leukocyte antigen-DRB1 with anti-cyclic citrullinated peptide autoantibodies in Saudi patients with rheumatoid arthritis
por: Adwan, Marwan Hmoud
Publicado: (2017)

Evaluation of a fit-for-purpose assay to monitor antigen-specific functional CD4+ T-cell subpopulations in rheumatoid arthritis using flow cytometry–based peptide-MHC class-II tetramer staining
por: Patel, Swati, et al.
Publicado: (2021)

HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome
por: Illing, Patricia T., et al.
Publicado: (2018)

Diagnostic value of anti-cyclic citrullinated peptides and association with HLA-DRB1 shared epitope alleles in African rheumatoid arthritis patients
por: Singwe-Ngandeu, Madeleine, et al.
Publicado: (2010)

Highly Divergent T-cell Receptor Binding Modes Underlie Specific Recognition of a Bulged Viral Peptide bound to a Human Leukocyte Antigen Class I Molecule
por: Liu, Yu Chih, et al.
Publicado: (2013)

Long-term follow-up of patients with anti-cyclic citrullinated peptide antibody-positive connective tissue disease: a retrospective observational study including information on the HLA-DRB1 allele and citrullination dependency
por: Iwasaki, Takeshi, et al.
Publicado: (2020)

Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis
por: van der Helm-van Mil, Annette HM, et al.
Publicado: (2005)

Anti-citrullinated protein antibodies contribute to platelet activation in rheumatoid arthritis
por: Habets, Kim L.L., et al.
Publicado: (2015)

Diagnostic performance and predictive value of rheumatoid factor, anti-cyclic-citrullinated peptide antibodies and HLA-DRB1 locus genes in rheumatoid arthritis
por: Fathi, Nihal A, et al.
Publicado: (2008)

A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis
por: Berglin, Ewa, et al.
Publicado: (2004)

Human blood MAIT cell subsets defined using MR1 tetramers
por: Gherardin, Nicholas A, et al.
Publicado: (2018)

The balance of interleukin‐12 and interleukin‐23 determines the bias of MAIT1 versus MAIT17 responses during bacterial infection
por: Wang, Huimeng, et al.
Publicado: (2022)

Assembly of the Type II Secretion System such as Found in Vibrio cholerae Depends on the Novel Pilotin AspS
por: Dunstan, Rhys A., et al.
Publicado: (2013)

DYNAMICS OF HUMAN MUCOSAL-ASSOCIATED INVARIANT T CELL REPERTOIRES ACROSS THE HUMAN LIFE SPAN
por: Loh, Liyen, et al.
Publicado: (2019)

Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection
por: Zhao, Zhe, et al.
Publicado: (2021)

Protective Efficacy of Cross-Reactive CD8(+) T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold
por: Valkenburg, Sophie A., et al.
Publicado: (2010)

Scabies Mite Inactive Serine Proteases Are Potent Inhibitors of the Human Complement Lectin Pathway
por: Reynolds, Simone L., et al.
Publicado: (2014)

DRB1, DRB2 and DRB4 Are Required for Appropriate Regulation of the microRNA399/PHOSPHATE2 Expression Module in Arabidopsis thaliana
por: Pegler, Joseph L., et al.
Publicado: (2019)

MAIT cells protect against pulmonary Legionella longbeachae infection
por: Wang, Huimeng, et al.
Publicado: (2018)

Fine-specificity of the antibodies against citrullinated protein response is influenced by shared epitope alleles
por: Verpoort, KN, et al.
Publicado: (2007)

Effects of Human Leukocyte Antigen DRB1 Genetic Polymorphism on Anti-Cyclic Citrullinated Peptide (ANTI-CCP) and Rheumatoid Factor (RF) Expression in Rheumatoid Arthritis (RA) Patients
por: Chen, Yu-Chia, et al.
Publicado: (2023)

The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA
por: Suwannalai, Parawee, et al.
Publicado: (2011)

Absence of Epstein-Barr virus DNA in anti-citrullinated protein antibody-expressing B cells of patients with rheumatoid arthritis
por: Kroos, Sanne, et al.
Publicado: (2022)

Protease-associated import systems are widespread in Gram-negative bacteria
por: Grinter, Rhys, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_267bn67ia3q5pcnr1t19rsene9