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The skin is an important bulwark of acquired immunity against intestinal helminths

Once animals have experienced a helminthic infection, they often show stronger protective immunity against subsequent infections. Although helminthic infections are well known to elicit Th2-type immune responses, it remains ill-defined where and how acquired protection is executed. Here we show that...

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Autores principales: Obata-Ninomiya, Kazushige, Ishiwata, Kenji, Tsutsui, Hidemitsu, Nei, Yuichiro, Yoshikawa, Soichiro, Kawano, Yohei, Minegishi, Yoshiyuki, Ohta, Nobuo, Watanabe, Naohiro, Kanuka, Hirotaka, Karasuyama, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832932/
https://www.ncbi.nlm.nih.gov/pubmed/24166714
http://dx.doi.org/10.1084/jem.20130761
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author Obata-Ninomiya, Kazushige
Ishiwata, Kenji
Tsutsui, Hidemitsu
Nei, Yuichiro
Yoshikawa, Soichiro
Kawano, Yohei
Minegishi, Yoshiyuki
Ohta, Nobuo
Watanabe, Naohiro
Kanuka, Hirotaka
Karasuyama, Hajime
author_facet Obata-Ninomiya, Kazushige
Ishiwata, Kenji
Tsutsui, Hidemitsu
Nei, Yuichiro
Yoshikawa, Soichiro
Kawano, Yohei
Minegishi, Yoshiyuki
Ohta, Nobuo
Watanabe, Naohiro
Kanuka, Hirotaka
Karasuyama, Hajime
author_sort Obata-Ninomiya, Kazushige
collection PubMed
description Once animals have experienced a helminthic infection, they often show stronger protective immunity against subsequent infections. Although helminthic infections are well known to elicit Th2-type immune responses, it remains ill-defined where and how acquired protection is executed. Here we show that skin-invading larvae of the intestinal helminth Nippostrongylus brasiliensis are surrounded by skin-infiltrating cells and are prevented from migrating out of infected skin during the second but not the first infection. B cell– or IgE receptor FcεRI–deficient mice showed impaired larval trapping in the skin. Selective ablation of basophils, but not mast cells, abolished the larval trapping, leading to increased worm burden in the lung and hence severe lung injury. Skin-infiltrating basophils produced IL-4 that in turn promoted the generation of M2-type macrophages, leading to the larval trapping in the skin through arginase-1 production. Basophils had no apparent contribution to worm expulsion from the intestine. This study thus reveals a novel mode of acquired antihelminth immunity, in which IgE-armed basophils mediate skin trapping of larvae, thereby limiting lung injury caused by larval migration.
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spelling pubmed-38329322014-05-18 The skin is an important bulwark of acquired immunity against intestinal helminths Obata-Ninomiya, Kazushige Ishiwata, Kenji Tsutsui, Hidemitsu Nei, Yuichiro Yoshikawa, Soichiro Kawano, Yohei Minegishi, Yoshiyuki Ohta, Nobuo Watanabe, Naohiro Kanuka, Hirotaka Karasuyama, Hajime J Exp Med Article Once animals have experienced a helminthic infection, they often show stronger protective immunity against subsequent infections. Although helminthic infections are well known to elicit Th2-type immune responses, it remains ill-defined where and how acquired protection is executed. Here we show that skin-invading larvae of the intestinal helminth Nippostrongylus brasiliensis are surrounded by skin-infiltrating cells and are prevented from migrating out of infected skin during the second but not the first infection. B cell– or IgE receptor FcεRI–deficient mice showed impaired larval trapping in the skin. Selective ablation of basophils, but not mast cells, abolished the larval trapping, leading to increased worm burden in the lung and hence severe lung injury. Skin-infiltrating basophils produced IL-4 that in turn promoted the generation of M2-type macrophages, leading to the larval trapping in the skin through arginase-1 production. Basophils had no apparent contribution to worm expulsion from the intestine. This study thus reveals a novel mode of acquired antihelminth immunity, in which IgE-armed basophils mediate skin trapping of larvae, thereby limiting lung injury caused by larval migration. The Rockefeller University Press 2013-11-18 /pmc/articles/PMC3832932/ /pubmed/24166714 http://dx.doi.org/10.1084/jem.20130761 Text en © 2013 Obata-Ninomiya et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Article
Obata-Ninomiya, Kazushige
Ishiwata, Kenji
Tsutsui, Hidemitsu
Nei, Yuichiro
Yoshikawa, Soichiro
Kawano, Yohei
Minegishi, Yoshiyuki
Ohta, Nobuo
Watanabe, Naohiro
Kanuka, Hirotaka
Karasuyama, Hajime
The skin is an important bulwark of acquired immunity against intestinal helminths
title The skin is an important bulwark of acquired immunity against intestinal helminths
title_full The skin is an important bulwark of acquired immunity against intestinal helminths
title_fullStr The skin is an important bulwark of acquired immunity against intestinal helminths
title_full_unstemmed The skin is an important bulwark of acquired immunity against intestinal helminths
title_short The skin is an important bulwark of acquired immunity against intestinal helminths
title_sort skin is an important bulwark of acquired immunity against intestinal helminths
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832932/
https://www.ncbi.nlm.nih.gov/pubmed/24166714
http://dx.doi.org/10.1084/jem.20130761
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