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The skin is an important bulwark of acquired immunity against intestinal helminths
Once animals have experienced a helminthic infection, they often show stronger protective immunity against subsequent infections. Although helminthic infections are well known to elicit Th2-type immune responses, it remains ill-defined where and how acquired protection is executed. Here we show that...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832932/ https://www.ncbi.nlm.nih.gov/pubmed/24166714 http://dx.doi.org/10.1084/jem.20130761 |
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author | Obata-Ninomiya, Kazushige Ishiwata, Kenji Tsutsui, Hidemitsu Nei, Yuichiro Yoshikawa, Soichiro Kawano, Yohei Minegishi, Yoshiyuki Ohta, Nobuo Watanabe, Naohiro Kanuka, Hirotaka Karasuyama, Hajime |
author_facet | Obata-Ninomiya, Kazushige Ishiwata, Kenji Tsutsui, Hidemitsu Nei, Yuichiro Yoshikawa, Soichiro Kawano, Yohei Minegishi, Yoshiyuki Ohta, Nobuo Watanabe, Naohiro Kanuka, Hirotaka Karasuyama, Hajime |
author_sort | Obata-Ninomiya, Kazushige |
collection | PubMed |
description | Once animals have experienced a helminthic infection, they often show stronger protective immunity against subsequent infections. Although helminthic infections are well known to elicit Th2-type immune responses, it remains ill-defined where and how acquired protection is executed. Here we show that skin-invading larvae of the intestinal helminth Nippostrongylus brasiliensis are surrounded by skin-infiltrating cells and are prevented from migrating out of infected skin during the second but not the first infection. B cell– or IgE receptor FcεRI–deficient mice showed impaired larval trapping in the skin. Selective ablation of basophils, but not mast cells, abolished the larval trapping, leading to increased worm burden in the lung and hence severe lung injury. Skin-infiltrating basophils produced IL-4 that in turn promoted the generation of M2-type macrophages, leading to the larval trapping in the skin through arginase-1 production. Basophils had no apparent contribution to worm expulsion from the intestine. This study thus reveals a novel mode of acquired antihelminth immunity, in which IgE-armed basophils mediate skin trapping of larvae, thereby limiting lung injury caused by larval migration. |
format | Online Article Text |
id | pubmed-3832932 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-38329322014-05-18 The skin is an important bulwark of acquired immunity against intestinal helminths Obata-Ninomiya, Kazushige Ishiwata, Kenji Tsutsui, Hidemitsu Nei, Yuichiro Yoshikawa, Soichiro Kawano, Yohei Minegishi, Yoshiyuki Ohta, Nobuo Watanabe, Naohiro Kanuka, Hirotaka Karasuyama, Hajime J Exp Med Article Once animals have experienced a helminthic infection, they often show stronger protective immunity against subsequent infections. Although helminthic infections are well known to elicit Th2-type immune responses, it remains ill-defined where and how acquired protection is executed. Here we show that skin-invading larvae of the intestinal helminth Nippostrongylus brasiliensis are surrounded by skin-infiltrating cells and are prevented from migrating out of infected skin during the second but not the first infection. B cell– or IgE receptor FcεRI–deficient mice showed impaired larval trapping in the skin. Selective ablation of basophils, but not mast cells, abolished the larval trapping, leading to increased worm burden in the lung and hence severe lung injury. Skin-infiltrating basophils produced IL-4 that in turn promoted the generation of M2-type macrophages, leading to the larval trapping in the skin through arginase-1 production. Basophils had no apparent contribution to worm expulsion from the intestine. This study thus reveals a novel mode of acquired antihelminth immunity, in which IgE-armed basophils mediate skin trapping of larvae, thereby limiting lung injury caused by larval migration. The Rockefeller University Press 2013-11-18 /pmc/articles/PMC3832932/ /pubmed/24166714 http://dx.doi.org/10.1084/jem.20130761 Text en © 2013 Obata-Ninomiya et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Article Obata-Ninomiya, Kazushige Ishiwata, Kenji Tsutsui, Hidemitsu Nei, Yuichiro Yoshikawa, Soichiro Kawano, Yohei Minegishi, Yoshiyuki Ohta, Nobuo Watanabe, Naohiro Kanuka, Hirotaka Karasuyama, Hajime The skin is an important bulwark of acquired immunity against intestinal helminths |
title | The skin is an important bulwark of acquired immunity against intestinal helminths |
title_full | The skin is an important bulwark of acquired immunity against intestinal helminths |
title_fullStr | The skin is an important bulwark of acquired immunity against intestinal helminths |
title_full_unstemmed | The skin is an important bulwark of acquired immunity against intestinal helminths |
title_short | The skin is an important bulwark of acquired immunity against intestinal helminths |
title_sort | skin is an important bulwark of acquired immunity against intestinal helminths |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832932/ https://www.ncbi.nlm.nih.gov/pubmed/24166714 http://dx.doi.org/10.1084/jem.20130761 |
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