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Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRγ activation

Tumor metastasis and lack of NKG2D ligand (NKG2DL) expression are associated with poor prognosis in patients with colon cancer. Here, we found that spironolactone (SPIR), an FDA-approved diuretic drug with a long-term safety profile, can up-regulate NKG2DL expression in multiple colon cancer cell li...

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Detalles Bibliográficos
Autores principales:	Leung, Wai-Hang, Vong, Queenie P., Lin, Wenwei, Janke, Laura, Chen, Taosheng, Leung, Wing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832934/ https://www.ncbi.nlm.nih.gov/pubmed/24190430 http://dx.doi.org/10.1084/jem.20122292

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