Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

Somatic Addition of Sex Combs Like 1 (ASXL1) mutations occur in 10–30% of patients with myeloid malignancies, most commonly in myelodysplastic syndromes (MDSs), and are associated with adverse outcome. Germline ASXL1 mutations occur in patients with Bohring-Opitz syndrome. Here, we show that constit...

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Detalles Bibliográficos
Autores principales: Abdel-Wahab, Omar, Gao, Jie, Adli, Mazhar, Dey, Anwesha, Trimarchi, Thomas, Chung, Young Rock, Kuscu, Cem, Hricik, Todd, Ndiaye-Lobry, Delphine, LaFave, Lindsay M., Koche, Richard, Shih, Alan H., Guryanova, Olga A., Kim, Eunhee, Li, Sheng, Pandey, Suveg, Shin, Joseph Y., Telis, Leon, Liu, Jinfeng, Bhatt, Parva K., Monette, Sebastien, Zhao, Xinyang, Mason, Christopher E., Park, Christopher Y., Bernstein, Bradley E., Aifantis, Iannis, Levine, Ross L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832937/
https://www.ncbi.nlm.nih.gov/pubmed/24218140
http://dx.doi.org/10.1084/jem.20131141

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