Cargando…

5-Lipoxygenase Deficiency Reduces Acetaminophen-Induced Hepatotoxicity and Lethality

5-Lipoxygenase (5-LO) converts arachidonic acid into leukotrienes (LTs) and is involved in inflammation. At present, the participation of 5-LO in acetaminophen (APAP)-induced hepatotoxicity and liver damage has not been addressed. 5-LO deficient (5-LO(−/−)) mice and background wild type mice were ch...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hohmann, Miriam S. N., Cardoso, Renato D. R., Pinho-Ribeiro, Felipe A., Crespigio, Jefferson, Cunha, Thiago M., Alves-Filho, José C., da Silva, Rosiane V., Pinge-Filho, Phileno, Ferreira, Sergio H., Cunha, Fernando Q., Casagrande, Rubia, Verri, Waldiceu A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832964/ https://www.ncbi.nlm.nih.gov/pubmed/24288682 http://dx.doi.org/10.1155/2013/627046

Ejemplares similares

Quercetin Reduces Ehrlich Tumor-Induced Cancer Pain in Mice
por: Calixto-Campos, Cassia, et al.
Publicado: (2015)

Contribution of spinal cord glial cells to L. amazonensis experimental infection-induced pain in BALB/c mice
por: Borghi, Sergio M., et al.
Publicado: (2019)

Experimental Trypanosoma cruzi Infection Induces Pain in Mice Dependent on Early Spinal Cord Glial Cells and NFκB Activation and Cytokine Production
por: Borghi, Sergio M., et al.
Publicado: (2021)

The Ehrlich Tumor Induces Pain-Like Behavior in Mice: A Novel Model of Cancer Pain for Pathophysiological Studies and Pharmacological Screening
por: Calixto-Campos, Cassia, et al.
Publicado: (2013)

Differences in cNOS/iNOS Activity during Resistance to Trypanosoma cruzi Infection in 5-Lipoxygenase Knockout Mice
por: Panis, Carolina, et al.
Publicado: (2019)

Aspirin Modulates Innate Inflammatory Response and Inhibits the Entry of Trypanosoma cruzi in Mouse Peritoneal Macrophages
por: Malvezi, Aparecida Donizette, et al.
Publicado: (2014)

Brief research report: Repurposing pentoxifylline to treat intense acute swimming–Induced delayed-onset muscle soreness in mice: Targeting peripheral and spinal cord nociceptive mechanisms
por: Borghi, Sergio M., et al.
Publicado: (2023)

Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice
por: Staurengo-Ferrari, Larissa, et al.
Publicado: (2018)

Naringenin: an analgesic and anti-inflammatory citrus flavanone
por: Manchope, Marília F., et al.
Publicado: (2016)

The Therapeutic Potential of Angeli’s Salt in Mitigating Acute Trypanosoma cruzi Infection in Mice
por: Hideko Tatakihara, Vera Lúcia, et al.
Publicado: (2023)

Metabolic syndrome agravates cardiovascular, oxidative and inflammatory dysfunction during the acute phase of Trypanosoma cruzi infection in mice
por: Lucchetti, Bruno Fernando Cruz, et al.
Publicado: (2019)

Budlein A, a Sesquiterpene Lactone From Viguiera robusta, Alleviates Pain and Inflammation in a Model of Acute Gout Arthritis in Mice
por: Fattori, Victor, et al.
Publicado: (2018)

Protective effects of natsumikan (Citrus natsudaidai) extract on acetaminophen-induced lethal hepatotoxicity in mice
por: Yamaura, Katsunori, et al.
Publicado: (2012)

Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation
por: Lourenco-Gonzalez, Yuri, et al.
Publicado: (2019)

Nitric Oxide Involvement in Cardiovascular Dysfunctions of Parkinson Disease
por: Martins-Pinge, Marli Cardoso, et al.
Publicado: (2022)

Impact of malnourishment on the pharmacokinetics of acetaminophen and susceptibility to acetaminophen hepatotoxicity
por: Zillen, Daan, et al.
Publicado: (2021)

Vinpocetine Reduces Carrageenan-Induced Inflammatory Hyperalgesia in Mice by Inhibiting Oxidative Stress, Cytokine Production and NF-κB Activation in the Paw and Spinal Cord
por: Ruiz-Miyazawa, Kenji W., et al.
Publicado: (2015)

Intense Acute Swimming Induces Delayed-Onset Muscle Soreness Dependent on Spinal Cord Neuroinflammation
por: Borghi, Sergio M., et al.
Publicado: (2022)

15d-PGJ(2)-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice
por: Ruiz-Miyazawa, Kenji W., et al.
Publicado: (2018)

Contribution of Nrf2 Modulation to the Mechanism of Action of Analgesic and Anti-inflammatory Drugs in Pre-clinical and Clinical Stages
por: Staurengo-Ferrari, Larissa, et al.
Publicado: (2019)

Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses
por: Fattori, Victor, et al.
Publicado: (2016)

Mitochondrial–Lysosomal Axis in Acetaminophen Hepatotoxicity
por: Moles, Anna, et al.
Publicado: (2018)

Role of Pyroptosis in Acetaminophen-Induced Hepatotoxicity
por: Jaeschke, Hartmut, et al.
Publicado: (2022)

Regeneration and Recovery after Acetaminophen Hepatotoxicity
por: Bhushan, Bharat, et al.
Publicado: (2023)

Acetaminophen Hepatotoxicity: Not as Simple as One Might Think! Introductory Comments on the Special Issue—Recent Advances in Acetaminophen Hepatotoxicity
por: Jaeschke, Hartmut
Publicado: (2022)

Quercetin Inhibits Peripheral and Spinal Cord Nociceptive Mechanisms to Reduce Intense Acute Swimming-Induced Muscle Pain in Mice
por: Borghi, Sergio M., et al.
Publicado: (2016)

Lipopolysaccharide Induces Inflammatory Hyperalgesia Triggering a TLR4/MyD88-Dependent Cytokine Cascade in the Mice Paw
por: Calil, Igor L., et al.
Publicado: (2014)

Ehrlich Tumor Induces TRPV1-Dependent Evoked and Non-Evoked Pain-like Behavior in Mice
por: Bertozzi, Mariana M., et al.
Publicado: (2022)

Silymarin prevents acetaminophen-induced hepatotoxicity in mice
por: Papackova, Zuzana, et al.
Publicado: (2018)

Characteristics and Outcomes of Acetaminophen Overdose and Hepatotoxicity in Thailand
por: Pholmoo, Natthiya, et al.
Publicado: (2019)

Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology
por: Ramachandran, Anup, et al.
Publicado: (2017)

Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update
por: Yoon, Eric, et al.
Publicado: (2016)

Possible Role of Extracellular Vesicles in Hepatotoxicity of Acetaminophen
por: Šrajer Gajdošik, Martina, et al.
Publicado: (2022)

Fluorine-thiol displacement probes for acetaminophen's hepatotoxicity
por: Prather, Benjamin L., et al.
Publicado: (2023)

Tempol, a Superoxide Dismutase Mimetic Agent, Inhibits Superoxide Anion-Induced Inflammatory Pain in Mice
por: Bernardy, Catia C. F., et al.
Publicado: (2017)

Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf-2 and the NO−cGMP−PKG−K(ATP)Channel Signaling Pathway
por: Manchope, Marília F., et al.
Publicado: (2016)

Data on expression of lipoxygenases-5 and -12 in the normal and acetaminophen-damaged liver
por: Suciu, Maria, et al.
Publicado: (2016)

Swimming Training Modulates Nitric Oxide-Glutamate Interaction in the Rostral Ventrolateral Medulla in Normotensive Conscious Rats
por: Raquel, Hiviny de A., et al.
Publicado: (2016)

The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model
por: Ben-Shachar, Rotem, et al.
Publicado: (2012)

Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity
por: Amaral, Sylvia S, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_3g5nogfusvnfn79ddo9p2d963a