Cargando…
Association of a FGFR-4 Gene Polymorphism with Bronchopulmonary Dysplasia and Neonatal Respiratory Distress
Background. Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease of premature birth, characterized by impaired alveolar development and inflammation. Pathomechanisms contributing to BPD are poorly understood. However, it is assumed that genetic factors predispose to BPD and other...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832980/ https://www.ncbi.nlm.nih.gov/pubmed/24288432 http://dx.doi.org/10.1155/2013/932356 |
_version_ | 1782291767924621312 |
---|---|
author | Rezvani, Milad Wilde, Juliane Vitt, Patricia Mailaparambil, Beena Grychtol, Ruth Krueger, Marcus Heinzmann, Andrea |
author_facet | Rezvani, Milad Wilde, Juliane Vitt, Patricia Mailaparambil, Beena Grychtol, Ruth Krueger, Marcus Heinzmann, Andrea |
author_sort | Rezvani, Milad |
collection | PubMed |
description | Background. Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease of premature birth, characterized by impaired alveolar development and inflammation. Pathomechanisms contributing to BPD are poorly understood. However, it is assumed that genetic factors predispose to BPD and other pulmonary diseases of preterm neonates, such as neonatal respiratory distress syndrome (RDS). For association studies, genes upregulated during alveolarization are major candidates for genetic analysis, for example, matrix metalloproteinases (MMPs) and fibroblast growth factors (FGFs) and their receptors (FGFR). Objective. Determining genetic risk variants in a Caucasian population of premature neonates with BPD and RDS. Methods. We genotyped 27 polymorphisms within 14 candidate genes via restriction fragment length polymorphism (RFLP): MMP-1, -2, -9, and -12, -16, FGF receptors 2 and 4, FGF-2, -3, -4, -7, and -18, Signal-Regulatory Protein α (SIRPA) and Thyroid Transcription Factor-1 (TTF-1). Results. Five single nucleotide polymorphisms (SNPs) in MMP-9, MMP-12, FGFR-4, FGF-3, and FGF-7 are associated (P < 0.05) with RDS, defined as surfactant application within the first 24 hours after birth. One of them, in FGFR-4 (rs1966265), is associated with both RDS (P = 0.003) and BPD (P = 0.023). Conclusion. rs1966265 in FGF receptor 4 is a possible genetic key variant in alveolar diseases of preterm newborns. |
format | Online Article Text |
id | pubmed-3832980 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38329802013-11-28 Association of a FGFR-4 Gene Polymorphism with Bronchopulmonary Dysplasia and Neonatal Respiratory Distress Rezvani, Milad Wilde, Juliane Vitt, Patricia Mailaparambil, Beena Grychtol, Ruth Krueger, Marcus Heinzmann, Andrea Dis Markers Clinical Study Background. Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease of premature birth, characterized by impaired alveolar development and inflammation. Pathomechanisms contributing to BPD are poorly understood. However, it is assumed that genetic factors predispose to BPD and other pulmonary diseases of preterm neonates, such as neonatal respiratory distress syndrome (RDS). For association studies, genes upregulated during alveolarization are major candidates for genetic analysis, for example, matrix metalloproteinases (MMPs) and fibroblast growth factors (FGFs) and their receptors (FGFR). Objective. Determining genetic risk variants in a Caucasian population of premature neonates with BPD and RDS. Methods. We genotyped 27 polymorphisms within 14 candidate genes via restriction fragment length polymorphism (RFLP): MMP-1, -2, -9, and -12, -16, FGF receptors 2 and 4, FGF-2, -3, -4, -7, and -18, Signal-Regulatory Protein α (SIRPA) and Thyroid Transcription Factor-1 (TTF-1). Results. Five single nucleotide polymorphisms (SNPs) in MMP-9, MMP-12, FGFR-4, FGF-3, and FGF-7 are associated (P < 0.05) with RDS, defined as surfactant application within the first 24 hours after birth. One of them, in FGFR-4 (rs1966265), is associated with both RDS (P = 0.003) and BPD (P = 0.023). Conclusion. rs1966265 in FGF receptor 4 is a possible genetic key variant in alveolar diseases of preterm newborns. Hindawi Publishing Corporation 2013 2013-10-31 /pmc/articles/PMC3832980/ /pubmed/24288432 http://dx.doi.org/10.1155/2013/932356 Text en Copyright © 2013 Milad Rezvani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Rezvani, Milad Wilde, Juliane Vitt, Patricia Mailaparambil, Beena Grychtol, Ruth Krueger, Marcus Heinzmann, Andrea Association of a FGFR-4 Gene Polymorphism with Bronchopulmonary Dysplasia and Neonatal Respiratory Distress |
title | Association of a FGFR-4 Gene Polymorphism with Bronchopulmonary Dysplasia and Neonatal Respiratory Distress |
title_full | Association of a FGFR-4 Gene Polymorphism with Bronchopulmonary Dysplasia and Neonatal Respiratory Distress |
title_fullStr | Association of a FGFR-4 Gene Polymorphism with Bronchopulmonary Dysplasia and Neonatal Respiratory Distress |
title_full_unstemmed | Association of a FGFR-4 Gene Polymorphism with Bronchopulmonary Dysplasia and Neonatal Respiratory Distress |
title_short | Association of a FGFR-4 Gene Polymorphism with Bronchopulmonary Dysplasia and Neonatal Respiratory Distress |
title_sort | association of a fgfr-4 gene polymorphism with bronchopulmonary dysplasia and neonatal respiratory distress |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832980/ https://www.ncbi.nlm.nih.gov/pubmed/24288432 http://dx.doi.org/10.1155/2013/932356 |
work_keys_str_mv | AT rezvanimilad associationofafgfr4genepolymorphismwithbronchopulmonarydysplasiaandneonatalrespiratorydistress AT wildejuliane associationofafgfr4genepolymorphismwithbronchopulmonarydysplasiaandneonatalrespiratorydistress AT vittpatricia associationofafgfr4genepolymorphismwithbronchopulmonarydysplasiaandneonatalrespiratorydistress AT mailaparambilbeena associationofafgfr4genepolymorphismwithbronchopulmonarydysplasiaandneonatalrespiratorydistress AT grychtolruth associationofafgfr4genepolymorphismwithbronchopulmonarydysplasiaandneonatalrespiratorydistress AT kruegermarcus associationofafgfr4genepolymorphismwithbronchopulmonarydysplasiaandneonatalrespiratorydistress AT heinzmannandrea associationofafgfr4genepolymorphismwithbronchopulmonarydysplasiaandneonatalrespiratorydistress |