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Regulation of Vascular Function on Posttranscriptional Level
Posttranscriptional control of gene expression is crucial for regulating plurality of proteins and functional plasticity of the proteome under (patho)physiologic conditions. Alternative splicing as well as micro (mi)RNA-mediated mechanisms play an important role for the regulation of protein express...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833109/ https://www.ncbi.nlm.nih.gov/pubmed/24288605 http://dx.doi.org/10.1155/2013/948765 |
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author | Eisenreich, Andreas |
author_facet | Eisenreich, Andreas |
author_sort | Eisenreich, Andreas |
collection | PubMed |
description | Posttranscriptional control of gene expression is crucial for regulating plurality of proteins and functional plasticity of the proteome under (patho)physiologic conditions. Alternative splicing as well as micro (mi)RNA-mediated mechanisms play an important role for the regulation of protein expression on posttranscriptional level. Both alternative splicing and miRNAs were shown to influence cardiovascular functions, such as endothelial thrombogenicity and the vascular tone, by regulating the expression of several vascular proteins and their isoforms, such as Tissue Factor (TF) or the endothelial nitric oxide synthase (eNOS). This review will summarize and discuss the latest findings on the (patho)physiologic role of alternative splicing processes as well as of miRNAs on modulation of vascular functions, such as coagulation, thrombosis, and regulation of the vascular tone. |
format | Online Article Text |
id | pubmed-3833109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38331092013-11-28 Regulation of Vascular Function on Posttranscriptional Level Eisenreich, Andreas Thrombosis Review Article Posttranscriptional control of gene expression is crucial for regulating plurality of proteins and functional plasticity of the proteome under (patho)physiologic conditions. Alternative splicing as well as micro (mi)RNA-mediated mechanisms play an important role for the regulation of protein expression on posttranscriptional level. Both alternative splicing and miRNAs were shown to influence cardiovascular functions, such as endothelial thrombogenicity and the vascular tone, by regulating the expression of several vascular proteins and their isoforms, such as Tissue Factor (TF) or the endothelial nitric oxide synthase (eNOS). This review will summarize and discuss the latest findings on the (patho)physiologic role of alternative splicing processes as well as of miRNAs on modulation of vascular functions, such as coagulation, thrombosis, and regulation of the vascular tone. Hindawi Publishing Corporation 2013 2013-10-31 /pmc/articles/PMC3833109/ /pubmed/24288605 http://dx.doi.org/10.1155/2013/948765 Text en Copyright © 2013 Andreas Eisenreich. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Eisenreich, Andreas Regulation of Vascular Function on Posttranscriptional Level |
title | Regulation of Vascular Function on Posttranscriptional Level |
title_full | Regulation of Vascular Function on Posttranscriptional Level |
title_fullStr | Regulation of Vascular Function on Posttranscriptional Level |
title_full_unstemmed | Regulation of Vascular Function on Posttranscriptional Level |
title_short | Regulation of Vascular Function on Posttranscriptional Level |
title_sort | regulation of vascular function on posttranscriptional level |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833109/ https://www.ncbi.nlm.nih.gov/pubmed/24288605 http://dx.doi.org/10.1155/2013/948765 |
work_keys_str_mv | AT eisenreichandreas regulationofvascularfunctiononposttranscriptionallevel |