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Regulation of Vascular Function on Posttranscriptional Level

Posttranscriptional control of gene expression is crucial for regulating plurality of proteins and functional plasticity of the proteome under (patho)physiologic conditions. Alternative splicing as well as micro (mi)RNA-mediated mechanisms play an important role for the regulation of protein express...

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Detalles Bibliográficos
Autor principal: Eisenreich, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833109/
https://www.ncbi.nlm.nih.gov/pubmed/24288605
http://dx.doi.org/10.1155/2013/948765
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author Eisenreich, Andreas
author_facet Eisenreich, Andreas
author_sort Eisenreich, Andreas
collection PubMed
description Posttranscriptional control of gene expression is crucial for regulating plurality of proteins and functional plasticity of the proteome under (patho)physiologic conditions. Alternative splicing as well as micro (mi)RNA-mediated mechanisms play an important role for the regulation of protein expression on posttranscriptional level. Both alternative splicing and miRNAs were shown to influence cardiovascular functions, such as endothelial thrombogenicity and the vascular tone, by regulating the expression of several vascular proteins and their isoforms, such as Tissue Factor (TF) or the endothelial nitric oxide synthase (eNOS). This review will summarize and discuss the latest findings on the (patho)physiologic role of alternative splicing processes as well as of miRNAs on modulation of vascular functions, such as coagulation, thrombosis, and regulation of the vascular tone.
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spelling pubmed-38331092013-11-28 Regulation of Vascular Function on Posttranscriptional Level Eisenreich, Andreas Thrombosis Review Article Posttranscriptional control of gene expression is crucial for regulating plurality of proteins and functional plasticity of the proteome under (patho)physiologic conditions. Alternative splicing as well as micro (mi)RNA-mediated mechanisms play an important role for the regulation of protein expression on posttranscriptional level. Both alternative splicing and miRNAs were shown to influence cardiovascular functions, such as endothelial thrombogenicity and the vascular tone, by regulating the expression of several vascular proteins and their isoforms, such as Tissue Factor (TF) or the endothelial nitric oxide synthase (eNOS). This review will summarize and discuss the latest findings on the (patho)physiologic role of alternative splicing processes as well as of miRNAs on modulation of vascular functions, such as coagulation, thrombosis, and regulation of the vascular tone. Hindawi Publishing Corporation 2013 2013-10-31 /pmc/articles/PMC3833109/ /pubmed/24288605 http://dx.doi.org/10.1155/2013/948765 Text en Copyright © 2013 Andreas Eisenreich. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Eisenreich, Andreas
Regulation of Vascular Function on Posttranscriptional Level
title Regulation of Vascular Function on Posttranscriptional Level
title_full Regulation of Vascular Function on Posttranscriptional Level
title_fullStr Regulation of Vascular Function on Posttranscriptional Level
title_full_unstemmed Regulation of Vascular Function on Posttranscriptional Level
title_short Regulation of Vascular Function on Posttranscriptional Level
title_sort regulation of vascular function on posttranscriptional level
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833109/
https://www.ncbi.nlm.nih.gov/pubmed/24288605
http://dx.doi.org/10.1155/2013/948765
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