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Prognostic Significance of NOTCH1 and FBXW7 Mutations in Pediatric T-ALL
The NOTCH signaling pathway plays important role in the development of multicellular organisms, as it regulates cell proliferation, survival, and differentiation. In adults, it is essential for the T- or B-lymphocyte lineage commitment. NOTCH1 and FBXW7 mutations both lead the activation of the NOTC...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833232/ https://www.ncbi.nlm.nih.gov/pubmed/20683149 http://dx.doi.org/10.3233/DMA-2010-0715 |