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Dominant-negative activity of the STAT3-Y705F mutant depends on the N-terminal domain
BACKGROUND: STAT3 is a transcription factor of central importance in chronic inflammation and cancer. In response to cytokine stimulation STAT3 is phosphorylated on a single tyrosine residue at position 705, dimerizes and accumulates in the nucleus to induce target gene expression. The substitution...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833267/ https://www.ncbi.nlm.nih.gov/pubmed/24192293 http://dx.doi.org/10.1186/1478-811X-11-83 |