Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosa

[Image: see text] 3-Oxo-acyl-acyl carrier protein (ACP) reductase (FabG) plays a key role in the bacterial fatty acid synthesis II system in pathogenic microorganisms, which has been recognized as a potential drug target. FabG catalyzes reduction of a 3-oxo-acyl-ACP intermediate during the elongatio...

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Autores principales: Cukier, Cyprian D., Hope, Anthony G., Elamin, Ayssar A., Moynie, Lucile, Schnell, Robert, Schach, Susanne, Kneuper, Holger, Singh, Mahavir, Naismith, James H., Lindqvist, Ylva, Gray, David W., Schneider, Gunter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833349/
https://www.ncbi.nlm.nih.gov/pubmed/24015914
http://dx.doi.org/10.1021/cb4005063

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