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Metformin Inhibits Expression and Secretion of PEDF in Adipocyte and Hepatocyte via Promoting AMPK Phosphorylation

Objective. Pigment epithelium-derived factor (PEDF) plays an important role in obesity-induced insulin resistance (IR). The study aims to investigate the effect of metformin, a widely used agent to improve IR, on PEDF production both in vivo and in vitro. Methods. SD rats were divided into normal co...

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Detalles Bibliográficos
Autores principales:	Yang, Shumin, Lv, Qiong, Luo, Ting, Liu, Lulu, Gao, Rufei, Chen, Shumei, Ye, Peng, Cheng, Qingfeng, Li, Qifu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833404/ https://www.ncbi.nlm.nih.gov/pubmed/24288442 http://dx.doi.org/10.1155/2013/429207

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