Markers of Inflammation and Risk of Coronary Heart Disease

Cardiovascular disease is the leading cause of global mortality, with coronary heart disease (CHD) its major manifestation. Although inflammation, the body’s response to noxious stimuli, is implicated in several stages of CHD development, the relevance of circulating levels of markers of inflammatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Sarwar, Nadeem, Thompson, Alexander J., Di Angelantonio, Emanuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2009
Materias:
Other
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833412/
https://www.ncbi.nlm.nih.gov/pubmed/19773611
http://dx.doi.org/10.3233/DMA-2009-0646
Descripción
Sumario:Cardiovascular disease is the leading cause of global mortality, with coronary heart disease (CHD) its major manifestation. Although inflammation, the body’s response to noxious stimuli, is implicated in several stages of CHD development, the relevance of circulating levels of markers of inflammation to CHD risk remains uncertain. This review summarizes available epidemiological evidence for four emerging inflammatory markers implicated in CHD (fibrinogen, C-reactive protein, lipoprotein-associated phospholipase A(2) and interleukin-6); considers their likely utility in cardiovascular risk prediction; and outlines areas of outstanding uncertainty.

Ejemplares similares