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A Polymorphism of the Corticotropin-Releasing Hormone Receptor 2 (CRHR2) and Preterm Birth
Our aim was to investigate whether a genetic variation in the corticotropin-releasing hormone receptor 2 gene might be associated with preterm birth. In this case-control study we evaluated the G/A polymorphism (rs2267717) in intron 2 of the corticotropin-releasing hormone receptor 2 gene in one hun...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833414/ https://www.ncbi.nlm.nih.gov/pubmed/20164545 http://dx.doi.org/10.3233/DMA-2010-0681 |
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author | Schmid, Maximilian Grimm, Christoph Leipold, Heinz Knöfler, Martin Haslinger, Peter Egarter, Christian |
author_facet | Schmid, Maximilian Grimm, Christoph Leipold, Heinz Knöfler, Martin Haslinger, Peter Egarter, Christian |
author_sort | Schmid, Maximilian |
collection | PubMed |
description | Our aim was to investigate whether a genetic variation in the corticotropin-releasing hormone receptor 2 gene might be associated with preterm birth. In this case-control study we evaluated the G/A polymorphism (rs2267717) in intron 2 of the corticotropin-releasing hormone receptor 2 gene in one hundred women with preterm birth and one hundred healthy women with at least one uncomplicated full term pregnancy and no history of preterm birth. No significant correlation was found between the presence of the investigated polymorphism and preterm birth (p = 0.9, odds ratio 0.9 [Confidence interval 0.5–1.7]). A dose dependent association of the investigated polymorphism, in women with preterm birth, with gestational age at delivery (p = 0.003) and birth weight was observed (p = 0.0001). However, no association between IUGR (n=10) with either one of the investigated genotypes (p = 0.3) was found. Stratified analysis within case group (i.e. PPROM vs. non-PPROM) revealed no significant difference in genotype distribution (p = 0.6). In conclusion, the investigated polymorphism does not increase the risk for preterm birth overall but might modulate the length of pregnancy in a dose dependent fashion in a series of Caucasian women. |
format | Online Article Text |
id | pubmed-3833414 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-38334142013-12-17 A Polymorphism of the Corticotropin-Releasing Hormone Receptor 2 (CRHR2) and Preterm Birth Schmid, Maximilian Grimm, Christoph Leipold, Heinz Knöfler, Martin Haslinger, Peter Egarter, Christian Dis Markers Other Our aim was to investigate whether a genetic variation in the corticotropin-releasing hormone receptor 2 gene might be associated with preterm birth. In this case-control study we evaluated the G/A polymorphism (rs2267717) in intron 2 of the corticotropin-releasing hormone receptor 2 gene in one hundred women with preterm birth and one hundred healthy women with at least one uncomplicated full term pregnancy and no history of preterm birth. No significant correlation was found between the presence of the investigated polymorphism and preterm birth (p = 0.9, odds ratio 0.9 [Confidence interval 0.5–1.7]). A dose dependent association of the investigated polymorphism, in women with preterm birth, with gestational age at delivery (p = 0.003) and birth weight was observed (p = 0.0001). However, no association between IUGR (n=10) with either one of the investigated genotypes (p = 0.3) was found. Stratified analysis within case group (i.e. PPROM vs. non-PPROM) revealed no significant difference in genotype distribution (p = 0.6). In conclusion, the investigated polymorphism does not increase the risk for preterm birth overall but might modulate the length of pregnancy in a dose dependent fashion in a series of Caucasian women. IOS Press 2010 2010-02-17 /pmc/articles/PMC3833414/ /pubmed/20164545 http://dx.doi.org/10.3233/DMA-2010-0681 Text en Copyright © 2010 Hindawi Publishing Corporation. |
spellingShingle | Other Schmid, Maximilian Grimm, Christoph Leipold, Heinz Knöfler, Martin Haslinger, Peter Egarter, Christian A Polymorphism of the Corticotropin-Releasing Hormone Receptor 2 (CRHR2) and Preterm Birth |
title | A Polymorphism of the Corticotropin-Releasing Hormone Receptor 2 (CRHR2) and Preterm Birth |
title_full | A Polymorphism of the Corticotropin-Releasing Hormone Receptor 2 (CRHR2) and Preterm Birth |
title_fullStr | A Polymorphism of the Corticotropin-Releasing Hormone Receptor 2 (CRHR2) and Preterm Birth |
title_full_unstemmed | A Polymorphism of the Corticotropin-Releasing Hormone Receptor 2 (CRHR2) and Preterm Birth |
title_short | A Polymorphism of the Corticotropin-Releasing Hormone Receptor 2 (CRHR2) and Preterm Birth |
title_sort | polymorphism of the corticotropin-releasing hormone receptor 2 (crhr2) and preterm birth |
topic | Other |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833414/ https://www.ncbi.nlm.nih.gov/pubmed/20164545 http://dx.doi.org/10.3233/DMA-2010-0681 |
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